N-913

(+)-Norpropoxyphene maleate solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Formula empirica (notazione di Hill): C₂₅H₃₁NO₆
• Numero CAS: 159208-83-0
• Peso molecolare: 441.52
• Numero CE: 200-659-6
• Codice UNSPSC: 41116107
• NACRES: NA.24

Proprietà

• Grado: certified reference material
• Livello qualitativo: 300
• Stato: liquid
• Caratteristiche: Snap-N-Spike^®/Snap-N-Shoot^®
• Confezionamento: ampule of 1 mL
• Produttore/marchio commerciale: Cerilliant^®
• Concentrazione: 1.0 mg/mL in methanol (as free base)
• tecniche: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• applicazioni: forensics and toxicology
• Formato: single component solution
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OC(=O)\C=C/C(O)=O.CCC(=O)O[C@@](Cc1ccccc1)([C@H](C)CNC)c2ccccc2
• InChI: 1S/C21H27NO2.C4H4O4/c1-4-20(23)24-21(17(2)16-22-3,19-13-9-6-10-14-19)15-18-11-7-5-8-12-18;5-3(6)1-2-4(7)8/h5-14,17,22H,4,15-16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,21+;/m1./s1; HCQPFYNZJNOOKN-YKNFWSLESA-N

Descrizione

Descrizione generale

Norpropoxyphene is a major urinary metabolite of the opioid analgesic drug propoxyphene. Norpropoxyphene′s toxicity makes the parent drug more likely to cause death from overdose compared to similar mild opioid analgesics. This analytical reference standard is suitable for use as a starting material in the preparation of calibrators or controls for LC/MS or GC/MS testing methods in clinical toxicology, urine drug testing, forensic analysis or pain prescription monitoring.

Applicazioni

• Forensic toxicology: (+)-Norpropoxyphene maleate is utilized in liquid chromatography-high-resolution mass spectrometry for the quantification of opioids and their derivatives in whole blood, demonstrating its application in forensic cases to analyze the involvement of these substances in fatal incidents (Feliu et al., 2020).


• Pharmacokinetic analysis: This compound plays a crucial role in the simultaneous quantitation of multiple opioids in human plasma, utilizing solid-phase extraction and gas chromatography/mass spectrometry. This method is validated for its application in assessing the cardiovascular safety of therapeutic doses, underlining its importance in clinical pharmacology (Fernández et al., 2017).


• Drug metabolism in maternal health: (+)-Norpropoxyphene maleate is used in studies focusing on the liquid chromatographic determination of propoxyphene and its metabolites in plasma and breast milk, offering insights into drug safety and metabolism in maternal health contexts (Kunka et al., 1985).

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H301 + H311 + H331,H370
• Consigli di prudenza: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organi bersaglio: Eyes
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 49.5 °F - closed cup
• Punto d’infiammabilità (°C): 9.7 °C - closed cup