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850459C

Avanti

16:0-20:4 PC

Avanti Research™ - A Croda Brand

Sinonimo/i:

1-hexadecanoyl-2--(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine; PAPC; PC(16:0/20:4(5Z,8Z,11Z,14Z))

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About This Item

Formula empirica (notazione di Hill):
C44H80NO8P
Numero CAS:
35418-58-7
Peso molecolare:
782.08
Numero MDL:
MFCD00171671
Codice UNSPSC:
51191904
NACRES:
NA.25

Descrizione

1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine, chloroform

Saggio

>99% (TLC)

Stato

liquid

Confezionamento

pkg of 1 × 2.5 mL (850459C-25mg)
pkg of 2 × 4 mL (850459C-200mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand

Concentrazione

10 mg/mL (850459C-25mg)
25 mg/mL (850459C-200mg)

Tipo di lipide

cardiolipins
phospholipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC)OCC[N+](C)(C)C

InChI

1S/C44H80NO8P/c1-6-8-10-12-14-16-18-20-21-22-23-25-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-24-19-17-15-13-11-9-7-2/h14,16,20-21,23,25,28,30,42H,6-13,15,17-19,22,24,26-27,29,31-41H2,1-5H3/b16-14-,21-20-,25-23-,30-28-/t42-/m1/s1
PUDHBQQGURLBGJ-IVFHWKNFSA-N

Descrizione generale

Phosphatidylcholine (PC) is one of the major glycerophospholipids of the eukaryotic membranes. PC is zwitterionic. PC is synthesized via two pathways in higher eukaryotes like the triple methylation of phosphatidylethanolamine and the cytidine diphosphate (CDP)-choline pathway.

Applicazioni

16:0-20:4 PC is suitable for use:
  • in the preparation of auto-oxidised phospholipid for electrospray ionisation mass spectroscopic (ESI-MS) analysis
  • in liposome preparation for the treatment of organoid
  • as antigen in enzyme linked immunosorbent assay (ELISA) for the detection of autoantibodies to phospholipids

Azioni biochim/fisiol

Phosphatidylcholine (PC) is essential for maintaining the structure and functions of the membrane. PC is the substrate for sphingomyelin synthesis. PC is the precursor for various second messenger like phosphatidic acid, lysophosphatidic acid, diacylglycerol. PC is the dominant phospholipid present in cancer and neo-neoplastic tissues. Level of 16:0-20:4 PC is less in multiple myeloma cells than in normal plasma cells.

Confezionamento

5 mL Clear Glass Sealed Ampule (850459C-200mg)
5 mL Clear Glass Sealed Ampule (850459C-25mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Comunemente ordinati con questo prodotto

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Classi di pericolo

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Organi bersaglio

Central nervous system, Liver,Kidney

Codice della classe di stoccaggio

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

does not flash

Punto d’infiammabilità (°C)

does not flash

Elenchi normativi

Forniamo informazioni su eventuali restrizioni prevalentemente per i prodotti chimici. Per altre tipologie di prodotto siamo in grado di fornire soltanto informazioni limitate. Nessuna segnalazione significa che nessuno dei componenti è citato in un elenco. È dovere dell’utilizzatore assicurarsi che il prodotto venga impiegato in maniera sicura e a norme di legge.

EU REACH Annex XVII (Restriction List)

CAS No.

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

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1,2-Dipalmitoyl-sn-glycero-3-phosphocholine ≥99% (TLC)

Sigma-Aldrich

P4329

1,2-Dipalmitoyl-sn-glycero-3-phosphocholine

18:0 PC (DSPC) Avanti Research™ - A Croda Brand

Avanti

850365P

18:0 PC (DSPC)

William W Turner et al.
Journal of medicinal chemistry, 55(18), 8178-8182 (2012-09-01)
Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a
Mohamad Navab et al.
Circulation, 109(25), 3215-3220 (2004-06-16)
These studies were designed to determine the mechanism of action of an oral apolipoprotein (apo) A-I mimetic peptide, D-4F, which previously was shown to dramatically reduce atherosclerosis in mice. Twenty minutes after 500 microg of D-4F was given orally to
Autoantibodies to oxidized low density lipoprotein in relation with coronary artery disease
Soto Y, et al.
Human Antibodies, 18(3), 109-117 (2009)
Stefan Uderhardt et al.
The Journal of experimental medicine, 214(7), 2121-2138 (2017-06-02)
Blood coagulation is essential for physiological hemostasis but simultaneously contributes to thrombotic disease. However, molecular and cellular events controlling initiation and propagation of coagulation are still incompletely understood. In this study, we demonstrate an unexpected role of eosinophils during plasmatic
Benjamin J Ansell et al.
Circulation, 108(22), 2751-2756 (2003-11-26)
The inflammatory/antiinflammatory properties of HDL were compared with HDL cholesterol in 2 groups of patients and in age- and sex-matched control subjects. Group 1 consisted of 26 patients not yet taking a statin who presented with coronary heart disease (CHD)
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Global Trade Item Number

SKUGTIN
850459C-200MG4061835227341
850459C-25MG4061835227358

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