L021000

DCA Deblock

with Dichloromethane

• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 200
• Tipo: for DNA synthesis; for DNA synthesis
• Nome Commerciale: Proligo Reagents
• Forma fisica: liquid
• Condizioni di stoccaggio: dry at room temperature
• Concentrazione: 42.2-51.6 g/L (DCA content, titration)
• Impurezze: ≤200 ppm water content (Karl Fischer)
• Colore: clear

Descrizione

Descrizione generale

Deblock solution contains dichloroacetic acid (DCA) in dichloromethane that assists in the removal of the dimethoxytrityl (DMT) protecting group from the 5′hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, before the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.

Nota sulla preparazione

Dicloromethane / Dichloroacetic acid 97/3 (v/v)

Altre note

Deblock solution containing dichloroacetic acid (DCA) in dichloromethane removes the dimethoxytrityl (DMT) protecting group from the 5′hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS07,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H315 - H318 - H336 - H351 - H360FD - H362
• Consigli di prudenza: P202 - P263 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Carc. 2 - Eye Dam. 1 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Central nervous system
• Codice della classe di stoccaggio: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3