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925225

Sigma-Aldrich

KB02yne

Sinonimo/i:

2-Chloro-1-(6-(hex-5-yn-1-yloxy)-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one, Functionalized scout fragment

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About This Item

Formula empirica (notazione di Hill):
C17H20ClNO2
Numero CAS:
2376152-06-4
Peso molecolare:
305.80
Numero MDL:
MFCD00003568
Codice UNSPSC:
12352101
NACRES:
NA.22

Stato

powder or crystals (or Solid or Liquid)

Livello qualitativo

100

Impiego in reazioni chimiche

reagent type: chemical modification reagent
reaction type: click chemistry

Temperatura di conservazione

2-8°C

Categorie correlate

Applicazioni

KB02yne is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile is the functionalized version of KB02 (912131).

Related useful products may include:
  • Cysteine-reactive fragments: KB02 (912131), KB03 (912654), KB05 (911798), sulfoxide (925136), CoLDR probe (923818)
  • Functionalized scout fragments: KB02-COOH (925047), KB05yne (925144)
  • Electrophilc degraders featuring scout fragments: KB02-SLF (914738), KB03-SLF (914975), KB05-SLF (913715), Biotin-SLF (914223)
  • Cysteine-reactive probes for chemoproteomics: IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059)

Technology spotlight: Proteomic Ligandability Assessment

Altre note

Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization

The Proteome-Wide Potential for Reversible Covalency at Cysteine

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

B2059

Biotin Polyethyleneoxide Iodoacetamide

699357

4-(Chloroacetyl)morpholine, 97%

911798

N-(4-Bromophenyl)-N-phenylacrylamide, ≥95%

912131

2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one, ≥95%

912654

N-(3,5-Bis(trifluoromethyl)phenyl)-2-chloroacetamide, ≥95%

914975

KB03-SLF, ≥95%

913715

KB05-SLF

914738

KB02-SLF, ≥95%

914223

Biotin-SLF

923818

N-(But-3-yn-1-yl)-2-(((2-oxo-2H-chromen-7-yl)oxy)methyl)acrylamide

925047

KB02-COOH

925144

KB05yne, ≥95%

925136

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Certificati d'analisi (COA)

Lot/Batch Number

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Kristine Senkane et al.
Angewandte Chemie (International ed. in English), 58(33), 11385-11389 (2019-06-22)
Reversible covalency, achieved with, for instance, highly electron-deficient olefins, offers a compelling strategy to design chemical probes and drugs that benefit from the sustained target engagement afforded by irreversible compounds, while avoiding permanent protein modification. Reversible covalency has mainly been

Global Trade Item Number

SKUGTIN
925225-10MG4065267461014

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