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923346

Sigma-Aldrich

1-(2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)-1H-pyrazole-4-carboxylic acid

Sinonimo/i:

Rigid linker for PROTAC® development

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About This Item

Formula empirica (notazione di Hill):
C15H21N3O4
Peso molecolare:
307.34
Numero MDL:
MFCD34602204
Codice UNSPSC:
12352106
NACRES:
NA.22

Stato

powder or crystals

Livello qualitativo

100

Impiego in reazioni chimiche

reagent type: linker

Gruppo funzionale

Boc
carboxylic acid

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(C(C=N1)=CN1C2CC3(C2)CN(C(OC(C)(C)C)=O)C3)=O

InChI

BCYRREPCVZENEY-UHFFFAOYSA-N

Applicazioni

1-(2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)-1H-pyrazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
923311
923338
923370
923419
923427

Altre note

Protein Degrader Building Blocks

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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