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901841

Sigma-Aldrich

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average Mn 5,000, PCL average Mn 5,000

Sinonimo/i:

NHS ester PEG-PCL diblock copolymer, NHS ester-PEG-PCL, PEG-b-PCL, PEG-PCL

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About This Item

Formula condensata:
C10H14NO5S[C2H4O]n[C6H10O2]mH
Codice UNSPSC:
12352005
NACRES:
NA.23

Stato

powder or solid

PM

PCL average Mn 5,000
PEG average Mn 5,000

Colore

white to off-white

Ind. polidispersione

≤1.3 (by GPC)

Temperatura di conservazione

−20°C

Categorie correlate

Applicazioni

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The NHS ester functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Articoli

Microfluidic-Assisted Manufacturing of Materials for Nanomedicine

Professor Nicola Tirelli (Istituto Italiano di Tecnologia, Italy) highlights the microfluidic-assisted method for fabricating well-defined and reproducible nanoparticles for drug delivery research.

Microfluidic-Assisted Manufacturing of Materials for Nanomedicine

Professor Nicola Tirelli (Istituto Italiano di Tecnologia, Italy) highlights the microfluidic-assisted method for fabricating well-defined and reproducible nanoparticles for drug delivery research.

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