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731765

Sigma-Aldrich

Poly(ethylene glycol) methyl ether maleimide

average Mn 2,000, maleimide, methoxy, chemical modification reagent thiol reactive

Sinonimo/i:

Polyethylene glycol, Methoxy PEG maleimide, PEG methyl ether maleimide

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About This Item

Formula condensata:
CH3O(CH2CH2O)nCH2CH2OC(O)CH2CH2CH2N[C(O)]2CHCH
Codice UNSPSC:
12162002
NACRES:
NA.23

Nome del prodotto

Poly(ethylene glycol) methyl ether maleimide, average Mn 2,000

Stato

solid

Livello qualitativo

100

PM

average Mn 2,000

Impiego in reazioni chimiche

reagent type: chemical modification reagent
reactivity: thiol reactive

Punto di fusione

48-52 °C

Mw/Mn

<1.1

Estremità Ω

maleimide

Estremità α

methoxy

Architettura del polimero

shape: linear
functionality: monofunctional

Applicazioni

Poly(ethylene glycol) methyl ether maleimide is a maleimide-functionalized poly(ethylene glycol). Due to the maleimide-functionalization, this material can be used to rapidly conjugate thiol-containing biomolecules, APIs, or targeting ligands.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
MKCP3844
MKCC9785
MKBQ2460V
MKBF1109V
MKBF1109

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Karina L Heredia et al.
Macromolecules, 42(7), 2360-2367 (2009-01-01)
In this report we describe a straightforward approach to synthesize polymers with end-groups that bind site-specifically to two different proteins. Telechelic biotin, maleimide poly(

Articoli

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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