471860
(1R)-(+)-(1-Amino-2-methylpropyl)phosphonic acid
98%
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About This Item
Formula condensata:
(CH3)2CHCH(NH2)P(O)(OH)2
Numero CAS:
Peso molecolare:
153.12
Numero MDL:
Codice UNSPSC:
12352116
ID PubChem:
NACRES:
NA.22
Prodotti consigliati
Livello qualitativo
Saggio
98%
Attività ottica
[α]20/D +1.0°, c = 1 in 1 M NaOH
Punto di fusione
272-277 °C (lit.)
Gruppo funzionale
amine
Stringa SMILE
CC(C)[C@H](N)P(O)(O)=O
InChI
1S/C4H12NO3P/c1-3(2)4(5)9(6,7)8/h3-4H,5H2,1-2H3,(H2,6,7,8)/t4-/m1/s1
DGSLPJDIFKVSIB-SCSAIBSYSA-N
Categorie correlate
Descrizione generale
The enantiodiscrimination of (1R)-(+)-(1-amino-2-methylpropyl)phosphonic acid from its enantiomer in the gas-phase can be done using ESI-MS-CID technique. [electrospray ionization-mass spectrometric detection-collision induced dissociation]
Applicazioni
Serves as an attractive substitute for amino carboxylic acids in biological systems. Exhibits interesting and useful properties as peptide analog, antiviral agent, hapten for the generation of catalytic antibodies, enzyme inhibitors, potent antibiotics, herbicides, and pesticides.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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Enantiodiscrimination of chiral a-aminophosphonic acids by mass spectrometry.
Paladini A, et al.
Chirality, 13(10), 707-711 (2001)
Nour Z Atwany et al.
Biology, 9(8) (2020-08-13)
Regulatory T cells (Tregs) are key players in the regulation of inflammatory responses. In this study, two natural molecules, namely, sparteine sulfate (SS) and harpagoside (Harp), were investigated for their ability to induce Tregs in human peripheral blood mononuclear cells
M C Allen et al.
Journal of medicinal chemistry, 32(7), 1652-1661 (1989-07-01)
The synthesis of five amino phosphorus derivatives, 1a-e, is described. The derivatives were incorporated into a series (18) of analogues of the 5-14 portion of angiotensinogen, in most cases at the scissile Leu-Val bond. The resultant compounds were tested in
Camp, N.P. et al.
Bioorganic & Medicinal Chemistry Letters, 2, 1047-1047 (1992)
J Bird et al.
Journal of medicinal chemistry, 37(1), 158-169 (1994-01-07)
The synthesis of a series of N-phosphonalkyl dipeptides 6 is described. Syntheses were devised that allowed the preparation of single diastereoisomers and the assignment of stereochemistry. The compounds were evaluated in vitro for their ability to inhibit the degradation of
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