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286044

Sigma-Aldrich

Harmine

98%

Sinonimo/i:

7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole

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About This Item

Formula empirica (notazione di Hill):
C13H12N2O
Numero CAS:
442-51-3
Peso molecolare:
212.25
Beilstein:
178813
Numero CE:
207-131-4
Numero MDL:
MFCD00004958
Codice UNSPSC:
12352100
ID PubChem:
24857229
NACRES:
NA.22

Livello qualitativo

100

Saggio

98%

Punto di fusione

262-264 °C (lit.)

Stringa SMILE

CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3

InChI

1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
BXNJHAXVSOCGBA-UHFFFAOYSA-N

Informazioni sul gene

human ... CDC2(983) , CYP2D6(1565)

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Descrizione generale

The combination index (CI, serves as a quantitative indicator of pharmacological interactions) for harmaline/harmine and methylene blue/harmine was studied.

Applicazioni

Harmine was used as a donor in the fluorescence resonance energy transfer (FRET) study between harmine and silver nanoparticles (AgNPs).

Azioni biochim/fisiol

Central nervous system stimulant.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
BCCC5443
BCBZ1702
BCBS6157V
BCBN8748V
BCBH0770V

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Michael F Santillo et al.
Toxicology in vitro : an international journal published in association with BIBRA, 28(3), 403-410 (2014-01-01)
Interactions among monoamine oxidase (MAO) inhibitors in drugs, botanicals, and dietary supplements may lead to unpredictable neurochemical dysfunction due to excessive inhibition or therapeutic invalidation. Often recombinant MAO or brain tissue homogenates have been used to evaluate MAO inhibitors such
Katie L Uhl et al.
Cancer cell international, 18, 82-82 (2018-07-07)
Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cytostatic and cytotoxic effects. Harmine is capable of blocking the activities
Mansour Debdab et al.
Journal of medicinal chemistry, 54(12), 4172-4186 (2011-05-28)
We here report on the synthesis, optimization, and biological characterization of leucettines, a family of kinase inhibitors derived from the marine sponge leucettamine B. Stepwise synthesis of analogues starting from the natural structure, guided by activity testing on eight purified
Mohammad Amjadi et al.
Luminescence : the journal of biological and chemical luminescence, 29(6), 689-694 (2013-11-30)
This article reports on a novel fluorescence resonance energy transfer (FRET) system between harmine and silver nanoparticles (AgNPs), in which harmine acts as the donor and AgNPs act as the acceptor. As a result of FRET, harmine fluorescence is quenched
Jose A Morales-García et al.
Scientific reports, 7(1), 5309-5309 (2017-07-15)
Banisteriopsis caapi is the basic ingredient of ayahuasca, a psychotropic plant tea used in the Amazon for ritual and medicinal purposes, and by interested individuals worldwide. Animal studies and recent clinical research suggests that B. caapi preparations show antidepressant activity
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