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SML0042

Sigma-Aldrich

Lazabemide hydrate

≥97% (HPLC)

Sinonimo/i:

N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrate, Ro 19-6327 hydrate

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About This Item

Formula empirica (notazione di Hill):
C8H10ClN3O · xH2O
Numero CAS:
103878-84-8
Peso molecolare:
199.64 (anhydrous basis)
Numero MDL:
MFCD20488051
Codice UNSPSC:
12352200
ID PubChem:
329825112
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥97% (HPLC)

Forma fisica

powder

Condizioni di stoccaggio

desiccated

Colore

white to tan

Solubilità

DMSO: ≥22 mg/mL

Ideatore

Roche

Temperatura di conservazione

room temp

Stringa SMILE

O.NCCNC(=O)c1ccc(Cl)cn1

InChI

1S/C8H10ClN3O.H2O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10;/h1-2,5H,3-4,10H2,(H,11,13);1H2
JYWYNPKXSLPWGV-UHFFFAOYSA-N

Applicazioni

Lazabemide hydrate may be used in cell signaling studies.

Azioni biochim/fisiol

Lazabemide is a selective and reversible monoamine oxidase B (MAO-B) inhibitor and Anti-Parkinson. Also it inhibits monoamine uptake at high concentrations (IC50 values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively).
Lazabemide is effective in treatment of Alzheimer′s disease and in combination with nicotine replacement therapy aids in smoking cessation.

Caratteristiche e vantaggi

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H319

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Javier Ballesteros et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 18(1), 55-61 (2007-06-16)
Previous studies have reported negative findings for the association among brain monoamine oxidase B (MAO-B) and suicidal behaviour. However those studies did not adequately control their main results for the influence of confounding variables such as age at death. We
V Petegnief et al.
Neuroscience, 94(1), 105-115 (1999-12-29)
Previous data from our laboratory indicate that 25 mM ibotenic acid induces intracellular calcifications in the rat basal forebrain. Because of the lack of specificity of ibotenic acid for a glutamate receptor subtype, a dose-response study with alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate was
Clinical trials of neuroprotection for Parkinson's disease.
Peter A LeWitt
Neurology, 63(7 Suppl 2), S23-S31 (2004-10-13)
Glaucia H Braun et al.
Journal of biomolecular structure & dynamics, 25(4), 347-355 (2007-12-21)
Monoamine oxidase is a flavoenzyme bound to the mitochondrial outer membranes of the cells, which is responsible for the oxidative deamination of neurotransmitter and dietary amines. It has two distinct isozymic forms, designated MAO-A and MAO-B, each displaying different substrate
Andrzej Dekundy et al.
Journal of neural transmission (Vienna, Austria : 1996), 118(12), 1703-1716 (2010-12-17)
Subtype 5 metabotropic glutamate receptors (mGluR5) are abundant in the basal ganglia, amygdala, septum, hippocampus, peripheral sensory neurones and dorsal horn of the spinal cord. Thus, mGluR5 has been implicated in central processes underlying movement control, emotion, learning, and nociception.
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