Passa al contenuto
Merck
Tutte le immagini(1)

Documenti

23181

Sigma-Aldrich

Chloromethyl chloroformate

≥98.0% (GC)

Sinonimo/i:

1-Chloromethyl chloroformate, Chloroformic acid chloromethyl ester, Chloromethoxycarbonyl chloride, Chloromethyl carbonochloridate, Chloromethyl chlorocarbonate

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula condensata:
ClCOOCH2Cl
Numero CAS:
22128-62-7
Peso molecolare:
128.94
Beilstein:
506426
Numero CE:
244-793-3
Numero MDL:
MFCD00077688
Codice UNSPSC:
12352100
ID PubChem:
57648023
NACRES:
NA.22

Saggio

≥98.0% (GC)

Forma fisica

liquid

Indice di rifrazione

n20/D 1.428

P. eboll.

107-108 °C (lit.)

Densità

1.450 g/mL at 20 °C

Temperatura di conservazione

2-8°C

Stringa SMILE

ClCOC(Cl)=O

InChI

1S/C2H2Cl2O2/c3-1-6-2(4)5/h1H2
JYWJULGYGOLCGW-UHFFFAOYSA-N

Applicazioni

Chloromethyl chloroformate was used as key reactant in the synthesis of:
  • novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid
  • highly water-soluble monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A
  • series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes

Pittogrammi

Skull and crossbonesCorrosion
GHS06,GHS05

Avvertenze

Danger

Indicazioni di pericolo

H314,H331

Classi di pericolo

Acute Tox. 3 Inhalation - Skin Corr. 1B

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

203.0 °F - closed cup

Punto d’infiammabilità (°C)

95 °C - closed cup

Dispositivi di protezione individuale

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 6

1 of 6

2,2,2-Trichloroethyl chloroformate 98%

Sigma-Aldrich

142077

2,2,2-Trichloroethyl chloroformate

Heptafluoro-2-iodopropane 98%

Sigma-Aldrich

342017

Heptafluoro-2-iodopropane

Ethyl chloroformate 97%

Sigma-Aldrich

185892

Ethyl chloroformate

Tetrazole solution suitable for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile

Sigma-Aldrich

88185

Tetrazole solution

(9-Fluorenylmethyl) chloroformate for synthesis

Sigma-Aldrich

8.18203

(9-Fluorenylmethyl) chloroformate

Isobutyl chloroformate 98%

Sigma-Aldrich

177989

Isobutyl chloroformate

Hoon Cho et al.
Archives of pharmacal research, 27(6), 662-669 (2004-07-31)
The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbonate at the 3'-positions of CsA with chloromethyl chloroformate, in the presence of a base to
Lina Ribeiro et al.
Archiv der Pharmazie, 340(1), 32-40 (2007-01-09)
Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O-->N intramolecular acyl transfer from the carbamate conjugate base. Novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid containing amino acid
Keivan Sadrerafi et al.
Drug design, development and therapy, 12, 987-995 (2018-05-08)
Our previous study indicated that carborane containing small-molecule 1-(hydroxymethyl)-7-(4'-(trans-3″-(3'″-pyridyl)acrylamido)butyl)-1,7-dicarbadodecaborane (hm-MC4-PPEA), was a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt). Nampt has been shown to be upregulated in most cancers and is a promising target for the treatment of many different types
E Carvalho et al.
Bioorganic & medicinal chemistry, 8(7), 1719-1725 (2000-09-08)
A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, and (iii) either the silver carboxylate or the carboxylic acids in the presence of silver carbonate. The hydrolysis

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.