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Documenti

119792

Sigma-Aldrich

Podocarpic acid

98%

Sinonimo/i:

(+)-Podocarpic acid, (1S)-1,2,3,4,4a,9,10,10a-Octahydro-6-hydroxy-1,4a-dimethyl-1-phenanthrenecarboxylic acid, (1S,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-6-hydroxy-1,4a-dimethyl-1-phenanthrenecarboxylic acid, Podocarpic acid (resin acid)

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About This Item

Formula empirica (notazione di Hill):
C17H22O3
Numero CAS:
5947-49-9
Peso molecolare:
274.35
Numero CE:
227-706-3
Numero MDL:
MFCD00074825
Codice UNSPSC:
12352002
ID PubChem:
24847299
NACRES:
NA.22

Saggio

98%

Forma fisica

solid

Attività ottica

[α]20/D +133°, c = 4 in ethanol

Punto di fusione

193-196 °C (lit.)

Stringa SMILE

[H][C@@]12CCc3ccc(O)cc3[C@@]1(C)CCC[C@]2(C)C(O)=O

InChI

1S/C17H22O3/c1-16-8-3-9-17(2,15(19)20)14(16)7-5-11-4-6-12(18)10-13(11)16/h4,6,10,14,18H,3,5,7-9H2,1-2H3,(H,19,20)/t14-,16-,17+/m1/s1
VJILEYKNALCDDV-OIISXLGYSA-N

Informazioni sul gene

human ... TNF(7124)

Categorie correlate

Applicazioni

  • (+)-Podocarpic acid as chiral template in the synthesis of aphidicolane, stemodane and stemarane diterpenoids: This article reviews the use of (+)-podocarpic acid in the synthesis of various diterpenoids, showcasing its utility in complex organic syntheses (La Bella et al., 2016).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sigma-Aldrich

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Rosin ≥95% (HPLC)

Sigma-Aldrich

SMB00582

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Sclareol 98%

Sigma-Aldrich

357995

Sclareol

Steviol ≥98% (HPLC), powder

Sigma-Aldrich

H8664

Steviol

E J Parish et al.
Journal of pharmaceutical sciences, 73(5), 694-696 (1984-05-01)
As a class, octahydrophenanthrene lactones, podolactones , and related podocarpic acid derivatives have been reported to possess a wide variety of biological activities, including antileukemic activity, inhibition of plant cell growth, and hormonal and anti-inflammatory properties. In the present study
W He et al.
Bioorganic & medicinal chemistry letters, 9(3), 469-474 (1999-03-26)
Podocarpic acid derivatives as cytokine (IL-1beta) release inhibitors are discussed.
Hany Nashaat Baraka
Planta medica, 76(8), 815-817 (2010-01-15)
Podocarpic acid was metabolized by Mucor ramannianus ATCC 9628, and Beauveria bassiana ATCC 7159 to afford two new metabolites, 2 alpha-hydroxy podocarpic acid and 11-hydroxy podocarpic acid, along with the known metabolite 13-hydroxy podocarbic acid. The identity of these metabolites
T A Söderberg et al.
Toxicology, 107(2), 99-109 (1996-02-22)
The present study was undertaken to assess and compare the in vitro cytotoxic effects of three resin acid analogues: dehydrobietic acid, podocarpic acid, O-methylpodocarpic acid; an essential oil from Australia (tea tree oil); and tapped oleoresin from Thailand, on human
D J Bennett et al.
Current medicinal chemistry, 15(2), 195-209 (2008-01-29)
The Liver X Receptor (LXR) alpha and beta isoforms are members of the type II nuclear receptor family which function as a heterodimer with the Retinoid X Receptor (RXR). Upon agonist binding, the formation of the LXR/RXR heterodimer takes place
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