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108448

Sigma-Aldrich

Cyanoacetamide

99%

Sinonimo/i:

2-Cyanoacetamide

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About This Item

Formula condensata:
NCCH2CONH2
Numero CAS:
107-91-5
Peso molecolare:
84.08
Beilstein:
878221
Numero CE:
203-531-8
Numero MDL:
MFCD00008024
Codice UNSPSC:
12352100
ID PubChem:
24846668
NACRES:
NA.22

Saggio

99%

Punto di fusione

119-121 °C (lit.)

Solubilità

cold water: soluble 1gm in 6.5ml

Gruppo funzionale

amide

Stringa SMILE

NC(=O)CC#N

InChI

1S/C3H4N2O/c4-2-1-3(5)6/h1H2,(H2,5,6)
DGJMPUGMZIKDRO-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

Cyanoacetamide is the starting reagent for vitamin B6 synthesis. It reacts with reducing carbohydrates in borate buffer to give intense fluorescence andis useful for the automated analysis of carbohydrates as borate complexes.

Cyanoacetamide is a highly reactive compound used as a reaction intermediate in condensation and substitution reactions.

Applicazioni

Cyanoacetamide was used in spectrofluorimetric method for the determination of some antihistaminic H1 receptor antagonist drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride. It may be used in fluorometric determination of 3,4-dihydroxyphenylalanine. It was used as post column fluorigenic derivatizing agent for the bio-analysis and pharmacokinetics of chitosan ester in rabbit serum.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

419.0 °F - closed cup

Punto d’infiammabilità (°C)

215 °C - closed cup

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
WXBD6820V
WXBD4092V
WXBD1966V
WXBC9074V
WXBC7475V

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Supelco

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N,N-Diethyl-2-cyanoacetoamide 97%

Sigma-Aldrich

761133

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Cyanoacetohydrazide 98%

Sigma-Aldrich

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Cyanoacetohydrazide

2-Cyano-N-ethylacetamide AldrichCPR

Sigma-Aldrich

OTV000131

2-Cyano-N-ethylacetamide

Hao Chen et al.
Scientific reports, 8(1), 13433-13433 (2018-09-09)
Early damage to transplanted organs initiates excess inflammation that can cause ongoing injury, a leading cause for late graft loss. The endothelial glycocalyx modulates immune reactions and chemokine-mediated haptotaxis, potentially driving graft loss. In prior work, conditional deficiency of the
Fluorimetric determination of reducing carbohydrates with 2-cyanoacetamide and application to automated analysis of carbohydrates as borate complexes.
Honda S, et al.
Analytical Chemistry, 52(7), 1079-1082 (1980)
Fluorometric determination of 3, 4-dihydroxyphenylalanine with 2-cyanoacetamide.
Liu Y, et al.
Journal of Fluorescence, 13(2), 123-128 (2003)
Spectrofluorimetric Determination Of Some H1 Receptor Antagonist Drugs In Pharmaceutical Formulations And Biological Fluids.
Ibrahim F, et al.
International Journal of Pharmaceutical Sciences and Research, 2(8), 2056-2072 (2011)
Gregg A Duncan et al.
Molecular therapy. Methods & clinical development, 9, 296-304 (2018-07-25)
Diffusion of the viral vectors evaluated in inhaled gene therapy clinical trials to date are largely hindered within airway mucus, which limits their access to, and transduction of, the underlying airway epithelium prior to clearance from the lung. Here, we
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