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Merck

APP

amyloid beta (A4) precursor protein

Sinonimi:
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
Specie:
ID UniProtKB:
ID gene:
  • Human(351) Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(11820) amyloid beta (A4) precursor protein
  • Rat(54226) amyloid beta (A4) precursor protein
  • fruit fly(39399) approximated
  • chicken(374198) amyloid beta (A4) precursor protein
  • domestic cat(101085564) amyloid beta (A4) precursor protein
  • cow(280722) amyloid beta (A4) precursor protein
  • dog(403407) amyloid beta (A4) precursor protein
  • naked mole-rat(101724743) amyloid beta (A4) precursor protein
  • domestic guinea pig(100715302) amyloid beta (A4) precursor protein
  • sheep(101111593) amyloid beta (A4) precursor protein

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ELISA

N° Catalogo
Descrizione
Specie
High Sensitivity Human Amyloid β42 ELISA, This High Sensitivity Human Amyloid β42 ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.,
Specie
human
Human APP / Amyloid Beta A4 Protein ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Specie
human
Kit ELISA per amiloide β42 cerebrale umana, This Human Amyloid β42 Brain ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.,
Specie
human
High Sensitivity Human Amyloid β40 ELISA, This High Sensitivity Human Amyloid β40 ELISA is used to measure & quantify Amyloid β40 levels in Neuroscience research.,
Specie
human
Human Amyloid β40 and Amyloid β42 Brain ELISA, ,
Specie
human

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
BTA-1, ≥98% (HPLC), solid,
Specie
human
Curcumin, from Curcuma longa (Turmeric), powder,
Specie
human
Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin),
Specie
human
Flurbiprofen, cyclooxygenase inhibitor,
Specie
human, rat

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anticorpo anti-APP A4, a.a. 66-81 di APP {NT}, clone 22C11, clone 22C11, Chemicon®, from mouse,
Reattività con
canine, fish, human, monkey, mouse, pig, rat
Applicazione
immunofluorescence
immunohistochemistry

western blot
Anticorpo anti-beta amiloide 1-42, Chemicon®, from rabbit,
Reattività con
chicken, human, mouse
Applicazione
ELISA
immunohistochemistry

western blot
Anticorpo anti-amiloide β, clone W0-2, clone WO2, from mouse,
Reattività con
human, mouse
Applicazione
ELISA
immunohistochemistry

western blot
Anticorpo anti-oligomeri di amiloide, αβ, serum, Chemicon®,
Reattività con
eukaryotes, human, mouse, rat
Applicazione
ELISA
immunofluorescence

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Amyloid Antibody, β 1-16, clone DE2, culture supernatant, clone DE2, Chemicon®,
Reattività con
bovine, human, monkey
Applicazione
ELISA
immunohistochemistry

western blot

Proteins

N° Catalogo
Descrizione
Specie
Frammento 1-42 della proteina β amiloide, ,
Specie
human
Amyloid β-Protein Fragment 25-35, ≥97% (HPLC),
Specie
human
Amyloid β Protein Fragment 1-40, ≥90% (HPLC), powder,
Specie
human
β Amyloid 1-42, aβ, ultra pure, HFIP, recombinant human, ,
Specie
human
β Amyloid 1-42, aβ, ultra pure, TFA, recombinant human, ,
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human APP,
Specie
human
MISSION® esiRNA, targeting mouse App,
Specie
mouse