跳转至内容

Hydrolysis-Sensitive Dithiolethione Prodrug Micelles.

Hydrolysis-Sensitive Dithiolethione Prodrug Micelles.

Macromolecular bioscience (2015-06-24)

Urara Hasegawa, Naoya Tateishi, Hiroshi Uyama, André J van der Vlies

摘要

Prodrug micelles carrying 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADT-OH), a compound possessing chemopreventive properties, are prepared from amphiphilic block copolymers linking ADT-OH via an ester bond using glycine (PAM-PGlyADT) and isoleucine linkers (PAM-PIleADT). The release of ADT-OH from the PAM-PIleADT micelles is much slower than the PAM-PGlyADT micelles. The PAM-PGlyADT micelles show comparable toxicity with ADT-OH in different cancer cell lines, whereas the PAM-PIleADT micelles are not toxic up to 400 µM. This ADT-ester prodrug micelle approach enables to modulate the release rate of ADT-OH and thus might find application in cancer therapy and prevention.

材料

货号

品牌

产品描述

Sigma-Aldrich

二甲基亚砜, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

Sigma-Aldrich

二甲基亚砜, ACS reagent, ≥99.9%

Sigma-Aldrich

三氟乙酸, ReagentPlus^®, 99%

Sigma-Aldrich

二甲基亚砜, for molecular biology

Sigma-Aldrich

甲醇, ACS reagent, ≥99.8%

Sigma-Aldrich

乙酸乙酯, ACS reagent, ≥99.5%

Sigma-Aldrich

N,N-二甲基甲酰胺, ACS reagent, ≥99.8%

Sigma-Aldrich

二氯甲烷, contains 40-150 ppm amylene as stabilizer, ACS reagent, ≥99.5%

Sigma-Aldrich

二甲基亚砜, sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

Sigma-Aldrich

过氧化氢溶液, contains inhibitor, 30 wt. % in H₂O, ACS reagent

Sigma-Aldrich

硫酸钠, ACS reagent, ≥99.0%, anhydrous, granular

Sigma-Aldrich

氯仿, contains 100-200 ppm amylenes as stabilizer, ≥99.5%

Sigma-Aldrich

二甲基亚砜, ReagentPlus^®, ≥99.5%

Sigma-Aldrich

二乙醚, anhydrous, ACS reagent, ≥99.0%, contains BHT as inhibitor

Sigma-Aldrich

硫酸钠, ACS reagent, ≥99.0%, anhydrous, powder

Sigma-Aldrich

过氧化氢溶液, 30 % (w/w) in H₂O, contains stabilizer

Sigma-Aldrich

二乙醚, ACS reagent, anhydrous, ≥99.0%, contains BHT as inhibitor

Sigma-Aldrich

三氟乙酸, puriss. p.a., suitable for HPLC, ≥99.0% (GC)

Sigma-Aldrich

碳酸氢钾, ACS reagent, 99.7%, powder, crystals or granules

Sigma-Aldrich

氧化铝, activated, basic, Brockmann I

Sigma-Aldrich

二甲基亚砜, ≥99.5% (GC), suitable for plant cell culture

Sigma-Aldrich

氯仿, contains ethanol as stabilizer, ACS reagent, ≥99.8%

Sigma-Aldrich

1,4-二氧六环, ACS reagent, ≥99.0%, contains ≤25 ppm BHT as stabilizer

Sigma-Aldrich

噻唑蓝, 98%

Sigma-Aldrich

二甲基亚砜, puriss. p.a., ACS reagent, ≥99.9% (GC)

Sigma-Aldrich

过氧化氢溶液, 50 wt. % in H₂O, stabilized

Sigma-Aldrich

噻唑蓝, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97.5% (HPLC)

Sigma-Aldrich

4-(二甲氨基)吡啶, ReagentPlus^®, ≥99%

Sigma-Aldrich

氧化铝, activated, neutral, Brockmann I

Sigma-Aldrich

N,N-二甲基甲酰胺, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.8% (GC)