1667508

Tobramycin

United States Pharmacopeia (USP) Reference Standard

• 别名: Nebramycin Factor 6, O-[3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)]-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1→4)]-2-deoxy-D-streptamine
• 经验公式（希尔记法）: C₁₈H₃₇N₅O₉
• CAS号: 32986-56-4
• 分子量: 467.51
• Beilstein: 1357507
• MDL號碼: MFCD00077885
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329751327
• NACRES: NA.24

属性

• 等級: pharmaceutical primary standard
• API 家族: tobramycin
• 製造商／商標名: USP
• 應用: pharmaceutical (small molecule)
• 形式: neat
• 儲存溫度: 2-8°C
• SMILES 字串: NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
• InChI: 1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11+,12+,13+,14-,15+,16-,17+,18+/m0/s1
• InChI 密鑰: NLVFBUXFDBBNBW-SNGYORCQSA-N

说明

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

應用

It is intended to be used as a USP reference standard in specified quality tests and assays.(1)
Also used to prepare the standard solution for identification and assay of tobramycin and its different dosage forms using thin-layer chromatography (TLC) and liquid chromatography (LC) combined with UV detection at 365 nm respectively, as prescribed in the United States Pharmacopeia (USP) for the following monographs:

• Tobramycin
• Tobramycin for Injection
• Tobramycin Ophthalmic Ointment
• Tobramycin Ophthalmic Solution
• Tobramycin Injection
• Tobramycin Sulfate
• Tobramycin and Dexamethasone Ophthalmic Suspension
• Tobramycin Inhalation Solution
• Tobramycin and Fluorometholone Acetate Ophthalmic Suspension
• Tobramycin and Dexamethasone Ophthalmic Ointment
  

生化／生理作用

Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

分析報告

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他說明

Sales restrictions may apply.

安全信息

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H361f
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Repr. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable