1250008

雌二醇

United States Pharmacopeia (USP) Reference Standard

• 别名: β-雌二醇, 17β-雌二醇, 1，3，5-雌三烯-3，17β-二醇, 3,17β-二羟基-1,3,5(10)-雌三烯, 二氢卵泡素
• 经验公式（希尔记法）: C₁₈H₂₄O₂
• CAS号: 50-28-2
• 分子量: 272.38
• Beilstein: 1914275
• MDL號碼: MFCD00003693
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329749749
• NACRES: NA.24

属性

• 等級: pharmaceutical primary standard
• API 家族: estradiol
• 製造商／商標名: USP
• mp: 176-180 °C (lit.)
• 應用: pharmaceutical (small molecule)
• 格式: neat
• SMILES 字串: O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
• InChI 密鑰: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• 基因資訊: human ... ESR1(2099)

说明

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

• Dehydroepiandrosterone with a high-fat diet treatment at inducing polycystic ovary syndrome in rat model: This study explores the impact of estradiol in a model of polycystic ovary syndrome, providing insights into hormone interactions and their implications in reproductive health (He et al., 2024).


• Ethanolic Extract of Xylopia aethiopica Attenuated Aluminum-Induced Ovarian Toxicity in Adult Female Wistar Rats: Research highlights the potential of estradiol-related compounds in mitigating heavy metal-induced ovarian damage, suggesting a protective role of estrogen receptor agonists in reproductive toxicology (Japhet et al., 2024).


• Connecting Bisphenol A Exposure to PCOS: Findings from a Case-Control Investigation: This study investigates the effects of environmental estrogens, mimicking estradiol, on the prevalence of polycystic ovary syndrome, emphasizing the importance of estrogen receptor interactions in environmental health studies (Patel et al., 2024).


• Combined collection systems of sewage and rainfall runoff seriously affect the spatial distributions of natural estrogens and their conjugates in river water: Insights from this study on the distribution of estrogenic compounds like estradiol in aquatic environments highlight significant implications for water quality and public health (Wu et al., 2024).


• Sex differences in the variability of fasting metabolism: This investigation into metabolic rate variations examines the role of estradiol in differing metabolic responses between sexes, contributing to a deeper understanding of hormonal impact on metabolic health (Bradshaw et al., 2024).

生化／生理作用

绝经前卵巢分泌的主要雌激素。雌激素通过调节基因转录并因此调节蛋白质合成来指导胚胎发生和青春期女性表型的发展。 它还诱导促性腺激素的产生，进而诱导排卵。 暴露于雌二醇会增加乳腺癌的发生率和增殖。

分析報告

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他說明

Sales restrictions may apply.

安全信息

• 象形圖: GHS08,GHS09
• 訊號詞: Danger
• 危險聲明: H351,H360FD,H362,H410
• 防範說明: P201 - P202 - P260 - P263 - P273 - P308 + P313
• 危險分類: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A
• 儲存類別代碼: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable