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Merck
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UC126

Sigma-Aldrich

4-羟基美芬妥英

别名:

(±)-5-乙基-5-(4-羟苯基)-3-甲基海因, (±)-5-乙基-5-(4-羟苯基)-3-甲基羟基香豆素-2,4-二酮

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About This Item

经验公式（希尔记法）:
C12H14N2O3
CAS号:
61837-65-8
分子量:
234.25
MDL號碼:
MFCD00142316
分類程式碼代碼:
12161501
PubChem物質ID:
24724640
NACRES:
NA.77

形狀

solid

品質等級

200

顏色

white

mp

153-154 °C

儲存溫度

2-8°C

SMILES 字串

CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2

InChI

1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)

InChI 密鑰

OQPLORUDZLXXPD-UHFFFAOYSA-N

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一般說明

美芬妥英的 YP2C19 代谢物。

應用

4-羟基苯乙妥英已被用于开发超高效液相色谱（UPLC）-串联质谱分析（MS/MS），以评估人尿或血浆样品中的细胞色素P450（CYP）探针药物及其相关代谢产物。4-羟基苯乙妥英还被用于开发一类基于亚2微米颗粒LC/MS/MS的方法来分析CYP450探针底物代谢产物。

生化／生理作用

4-羟基苯乙妥英分解代谢显示出了遗传多态性，并是细胞色素P450 2C19（CYP2C19）活性的一种直接指示剂。通过高效液相色谱对生物样品中4-羟基苯乙妥英的检测和定量已被充分的优化。

包裝

无底玻璃瓶。内含物在插入的融合锥体内。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
BGBC3367V
023M3903V
023M3903
496-012-1V
496-012-1

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High-performance liquid chromatographic determination of urinary 4?-hydroxymephenytoin, a metabolic marker for the hepatic enzyme CYP2C19, in humans
Xie HG, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 668(1), 125-131 (1995)
Simple and selective assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high-performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test
Tanaka M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 676(1), 87-94 (1996)
Nicolas A Stewart et al.
The Analyst, 136(3), 605-612 (2010-11-26)
The efficiency of drug metabolism by a single enzyme can be measured as the fractional metabolic clearance which can be used as a measure of whole body activity for that enzyme. Measurement of activity of multiple enzymes simultaneously is feasible
Paul D Rainville et al.
Rapid communications in mass spectrometry : RCM, 22(9), 1345-1350 (2008-04-03)
The measurement of cytochrome P450 (CYP450) isoenzyme inhibition is often done during evaluation of new chemical entities in drug discovery. Typical assay protocol consists of multiple CYP450 probe substrates incubated with selected drug candidates and CYP450. Results of the assay
Xiao-Ping Chen et al.
Clinical pharmacology and therapeutics, 73(3), 264-271 (2003-03-07)
This study was designed to define the effect of low-dose aspirin administration on the activity of cytochrome P450 (CYP) in normal human subjects. Aspirin, 50 mg daily, was given for 14 days to 18 nonsmoking healthy male volunteers. A modified
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