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化驗
≥98% (HPLC)
形狀
solid
顏色
white
mp
100-102 °C
溶解度
ethanol: soluble 12 mg/mL
0.1 M NaOH: soluble 4 mg/mL
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
CCCCNC(=O)NS(=O)(=O)c1ccc(CO)cc1
InChI
1S/C12H18N2O4S/c1-2-3-8-13-12(16)14-19(17,18)11-6-4-10(9-15)5-7-11/h4-7,15H,2-3,8-9H2,1H3,(H2,13,14,16)
InChI 密鑰
SJRHYONYKZIRPM-UHFFFAOYSA-N
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應用
4-羟基甲苯磺丁脲已用作标准品，用于测定从甲苯磺丁脲到4'-羟基甲苯磺丁脲的真菌生物转化。
包裝
无底玻璃瓶。内含物装在插入式熔锥内。
其他說明
甲苯磺丁脲的代谢物；通过 P450 酶的细胞色素 CYP2CIIC8 和 IIC9 亚家族形成。
準備報告
4-羟基甲苯磺丁脲可溶于乙醇（浓度为 12 mg/mL），也可溶于 0.1 MNaOH（浓度为 4 mg/mL）。它不溶于水。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Biotransformation of tolbutamide to 4'-hydroxytolbutamide by the fungus Cunninghamella blakesleeana.
Haihua Huang et al.
Applied microbiology and biotechnology, 72(3), 486-491 (2006-02-24)
The hypoglycemic drug tolbutamide is commonly used as a probe drug to evaluate CYP2C9 enzyme activity in terms of production of 4'-hydroxytolbutamide. In the present study, an initial screening of seven filamentous fungi was carried out to identify which was
D J Back et al.
British journal of pharmacology, 85(1), 121-126 (1985-05-01)
Tolbutamide has been used as a model drug for an examination of the effects of eleven substituted imidazole compounds on hepatic metabolism in vivo. The 1-substituted compounds 1-methylimidazole, miconazole, clotrimazole and ketoconazole produced marked alterations in tolbutamide kinetics (increased half-life
Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9.
J O Miners et al.
Methods in enzymology, 272, 139-145 (1996-01-01)
D J Back et al.
British journal of pharmacology, 81(3), 557-562 (1984-03-01)
The effects of various drugs on the pharmacokinetics of tolbutamide have been examined in the rat. Phenobarbitone pretreatment caused a significant decrease in half life and area under the curve (AUC) and a significant increase in clearance and volume of
A Rieutord et al.
Xenobiotica; the fate of foreign compounds in biological systems, 25(12), 1345-1354 (1995-12-01)
1. The metabolism of gliclazide to hydroxygliclazide has been investigated in Sprague-Dawley rat liver microsomes. 2. The kinetics of hydroxygliclazide formation are consistent with Michaelis-Menten kinetics (mean (+/- SD, n = 3) apparent K(m) and Vmax = 256 +/- 27
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