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品質等級
溶解度
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
DMSO: >6.5 mg/mL
ethanol: <8 mg/mL (warm)
H2O: insoluble
SMILES 字串
Brc1c(NC2=NCCN2)ccc3nccnc13
InChI
1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
InChI 密鑰
XYLJNLCSTIOKRM-UHFFFAOYSA-N
基因資訊
human ... ADRA1A(148) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
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應用
UK 14,304 已用于肠肌间神经元，以研究 R 型钙电流的抑制 。UK 14,304 也曾用于免疫荧光显微术分析 。
在心外膜冠状动脉培养中，UK 14,304 已用于激活细胞外信号调节激酶 (ERK)
生化／生理作用
UK 14,304 是 α2-肾上腺素受体激动剂。UK 14,304 抑制激素敏感型脂肪酶 (HSL) 活性并抑制脂肪组织中的脂肪生成。
特點和優勢
该化合物在受体分类和信号转导手册中α2-肾上腺素能受体页面中进行了详细介绍。想要浏览手册的其他页面， 请单击此处。
準備報告
UK 14,304 可溶于 45%（w/v）aq 2-羟丙基-β--环糊精（<0.8 mg/mL), DMSO (> 6.5 mg/mL）和乙醇（<8 mg/mL）。但它不溶于水。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Review alpha 2 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-2 adrenoreceptors.
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