Y3125

育亨宾 盐酸盐

≥98% (HPLC), powder, α2-adrenergic receptor antagonist

• 别名: 17-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride
• 经验公式（希尔记法）: C₂₁H₂₆N₂O₃ · HCl
• CAS号: 65-19-0
• 分子量: 390.90
• EC號碼: 200-600-4
• MDL號碼: MFCD00012674
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24277814
• NACRES: NA.77

属性

• product name: 育亨宾 盐酸盐, ≥98% (HPLC), powder
• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to off-white
• mp: 288-290 °C (dec.) (lit.)
• 溶解度: H₂O: 10 mg/mL
• SMILES 字串: Cl.COC(=O)[C@H]1[C@@H](O)CCC2CN3CCc4c([nH]c5ccccc45)C3CC12
• InChI: 1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19+;/m0./s1
• InChI 密鑰: PIPZGJSEDRMUAW-VJDCAHTMSA-N
• 基因資訊: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

说明

應用

Yohimbine hydrochloride has been:

• used to study its in vitro antiviral, antibacterial and antifungal activities and cytotoxicity
• used as a tyramine receptor blocker to oppose the effects of increased tyramine in relation with flight initiation and maintenance deficits in experimental flies
• used alone and as well as with brimonidine to study the neuroprotective effect of brimonidine in the presence of glutamate-induced neurotoxicity, oxidative stress and hypoxia on in vitro cultures of purified rat retinal ganglion cells

生化／生理作用

Yohimbine is derived from the Coryanthe yohimbe tree cortex. It is an alkaloid. Yohimbine hydrochloride is an α2-adrenergic receptor antagonist. It blocks the central α2-adrenergic receptors in the brain, thus preventing and reducing the effects of xylazine, an α2-adrenergic agonist. The sedative effects and respiratory depression that accompany xylazine administration are both antagonized and reversed by yohimbine. Yohimbine hydrochloride also produces an antidiuretic effect, and increases heart rate and blood pressure. It is useful in treating erectile dysfunction and promotes sexual functioning.

特點和優勢

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300 + H330
• 防範說明: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• 危險分類: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges