所有图片(1)
About This Item
经验公式（希尔记法）:
C8H17N3O2 · 2 HCl
CAS号:
分子量:
260.16
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.77
推荐产品
生物源
synthetic (organic)
化驗
≥97% (HPLC)
形狀
powder
溶解度
water: 50 mg/mL, clear, colorless
儲存溫度
−20°C
SMILES 字串
Cl.Cl.CC(=N)NCCCC[C@H](N)C(O)=O
InChI
1S/C8H17N3O2.2ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);2*1H/t7-;;/m0../s1
InChI 密鑰
OQIBCXRAFAHXMM-KLXURFKVSA-N
基因資訊
human ... NOS2(4843)
應用
L-N6-（1-亚氨乙基）赖氨酸二盐酸盐已被用作诱导型一氧化氮合酶（iNOS）抑制剂：
- 研究其对瘦素诱导的小鼠心肌细胞和脂肪细胞中纤维连接蛋白Ⅲ型域包含蛋白五（FNDC5）/鸢尾素的调节作用
- 研究其对瘦素诱导的肝细胞炎症的影响
- 阻断小鼠骨髓间充质基质细胞（BMSCs）中一氧化氮的生成
生化／生理作用
诱导型一氧化氮合酶（iNOS）的选择性抑制剂。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
W M Moore et al.
Journal of medicinal chemistry, 37(23), 3886-3888 (1994-11-11)
L-N6-(1-Iminoethyl)lysine (L-NIL) has been synthesized and is shown to be both a potent and selective inhibitor of mouse inducible nitric oxide synthase (miNOS). L-NIL has an IC50 of 3.3 microM for miNOS compared to an IC50 of 92 microM for
Sara Becerril et al.
Genes, 10(3) (2019-03-02)
iNOS deficiency in ob/ob mice improved liver inflammation and ECM remodeling-related genes, decreasing fibrosis, and metabolic dysfunction. The activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in hepatocytes, suggesting an important role of this
Jérémy Postat et al.
Immunity, 49(4), 654-665 (2018-09-30)
Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be
A Rodríguez et al.
International journal of obesity (2005), 39(3), 397-407 (2014-09-10)
BACKGROUND/OBJETIVES: Obese leptin-deficient ob/ob mice exhibit high adiposity and reduced muscle mass with leptin replacement promoting weight loss and inducing muscle accretion through PGC-1α-dependent mechanisms. Our aim was to analyze in vivo and in vitro the effect of leptin on
Uwe Lendeckel et al.
Molecular medicine reports, 12(2), 2253-2262 (2015-04-22)
A disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) belongs to the ADAM family of transmembrane proteins. Via proteolysis, cell adhesion, cell-cell fusion, cell-matrix interaction and membrane protein shedding, ADAM proteins are involved in normal brain development, and also in cancer
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