C5366

Chlorisondamine diiodide

≥98% (HPLC), white, solid

• 别名: 4,5,6,7-Tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-2H-isoindolium diiodide
• 经验公式（希尔记法）: C₁₄H₂₀Cl₄I₂N₂
• CAS号: 96750-66-2
• 分子量: 611.94
• MDL號碼: MFCD01074794
• 分類程式碼代碼: 12352116
• PubChem物質ID: 24724443
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: solid
• 儲存條件: protect from light
• 顏色: white
• 溶解度: H₂O: ≥2 mg/mL; DMSO: >20 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: [I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1
• InChI: 1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2
• InChI 密鑰: FPNVAOZHQUJJJQ-UHFFFAOYSA-L

说明

應用

Chlorisondamine diiodide has been used:

• as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
• as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
• as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress

生化／生理作用

Chlorisondamine diiodide mediates ganglionic and central blockade.

Irreversible, long-lasting nicotinic acetylcholine receptor antagonist.

特點和優勢

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形圖: GHS07,GHS09
• 訊號詞: Warning
• 危險聲明: H302,H400
• 防範說明: P273 - P301 + P312 + P330
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves