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生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
IRT537, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~50 kDa
物種活性
mouse, human
濃度
~2 mg/mL
技術
immunocytochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.25-0.5 using extracts of COS7 cells transfected with mouse Tis7
同型
IgG2a
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... IFRD1(3475)
mouse ... Ifrd1(15982)
rat ... Ifrd1(29596)
一般說明
The tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7), also known as interferon related developmental regulator 1 (FRD1), is mapped to human chromosome 7q31.1. The gene with 13 exons, spans about 52kb of genomic DNA. The encoded protein consists of 451 amino acids and is expressed in mature neutrophils.
免疫原
synthetic peptide corresponding to amino acids 30-47 of mouse Tis7, conjugated to KLH.
應用
Monoclonal Anti-TIS7 antibody produced in mouse has been used in western blot analysis.
生化／生理作用
Tetradecanoylphorbol-13-acetate-induced sequence 7 (TIS7)/interferon related developmental regulator 1(FRD1) is implicated in regulation of the proliferation and differentiation pathways induced by nerve growth factor (NGF). The encoded protein also plays a vital role in myocyte differentiation, and it modulates the nuclear factor-κB (NF-κB) pathway by influencing the activity of histone deacetylases and forming complexes with the p65 subunit of NFκB. Genetic variations in the gene is associated with the development of various diseases such as sensory/motor neuropathy with ataxia (SMNA), cystic fibrosis, lung disease and myelodysplastic syndrome (MDS). TIS7 is also implicated in regulation of airway inflammation.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
PC4/Tis7/IFRD1 stimulates skeletal muscle regeneration and is involved in myoblast differentiation as a regulator of MyoD and NF-kappaB
Micheli L, et al.
Test, 286(7), 5691-5707 (2011)
The IFRD1 (57460C>T Polymorphism) Gene: A Negative Report in Cystic Fibrosis Clinical Severity
de Lima Marson
Journal of Molecular and Genetic Medicine, 7, 2-8 (2013)
IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23.
Brkanac Z
American Journal of Human Genetics, 84, 692-697 (2009)
Mutated genes and driver pathways involved in myelodysplastic syndromes?a transcriptome sequencing based approach.
Liu L
Molecular Biosystems, 11, 2158-2166 (2015)
Wenbo Ma et al.
PloS one, 13(9), e0203402-e0203402 (2018-09-08)
Resistance to antitumor immunity can be promoted by the oncogenic pathways operational in human cancers, including the epidermal growth factor receptor (EGFR) pathway. Here we studied if and how EGFR downstream signaling in head and neck squamous cell carcinoma (HNSCC)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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