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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 48 kDa
物種活性
Drosophila
技術
western blot: 0.2-0.4 μg/mL using whole cell extract of the Schneider′s Drosophila Line 2 [D.mel.(2), SL2]
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
一般說明
γ-Tubulin (48 kDa) is a widely expressed and highly conserved protein within the microtubule organizing centers (MTOCs) or centrosome in eukaryotic cells.
γ-tubulin, mapped on human chromosome 17q21.2, codes for a member of the tubulin family. It is localized to the microtubule organizing centres. γ-tubulin consists of two isoforms tubulin γ 1 (TUBG1) and tubulin γ 2 (TUBG2) with 97.3% amino acid identity. In addition to these two isoforms, γ-tubulin pseudogene (TUBG1P) is also been identified on human chromosome 17. Human TUBG1 and TUBG2 transcripts are widely expressed in preimplantation embryos and the brain, respectively. γ-tubulin is a component of γ-tubulin ring complex (γ-TuRC), which has roughly the same diameter as a microtubule.
特異性
The sequence is highly specific for Drosophila γ-tubulin and is not found in γ-tubulin of other species or other members of the tubulin family such as α-, β-, δ-, and ε-tubulins.
免疫原
synthetic peptide corresponding to the C-terminus of Drosophila γ-tubulin (amino acids 441-457 with N-terminal added cysteine-glycine), conjugated to KLH.
應用
Anti-γ-Tubulin (QG-17) antibody has been used in immunoblotting and immunostaining.
生化／生理作用
γ-tubulin nucleates microtubule assembly throughout the mammalian cell cycle in vivo. In Aspergillus nidulans, γ-tubulin facilitates attachment of microtubules to the spindle pole body, nuclear division and microtubule assembly. Ubiquitination of γ-tubulin by breast cancer 1 protein (BRCA1) is a crucial step in the regulation of centrosome number. Overexpression of γ-tubulin is observed in lung cancer. Tubulin γ 2 (TUBG2) plays a vital role in cell growth. Aberration in the γ-tubulin gene alters microtubule assembly. The expression levels of γ-tubulin can be considered as an important prognostic indicator for patients with astrocytomas.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Overexpression of γ-tubulin in non-small cell lung cancer.
Maounis NF, et al.
Histology and Histopathology, 27, 1183-1194 (2012)
Michelle Kowanda et al.
Biology open, 5(8), 1040-1051 (2016-07-17)
The centrosome-associated proteins Ninein (Nin) and Ninein-like protein (Nlp) play significant roles in microtubule stability, nucleation and anchoring at the centrosome in mammalian cells. Here, we investigate Blastoderm specific gene 25D (Bsg25D), which encodes the only Drosophila protein that is
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.
Starita LM, et al.
Molecular and Cellular Biology, 24, 8457-8466 (2004)
Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation.
Joshi HC, et al.
Nature, 356, 80-83 (1992)
Gamma-tubulin is a component of the spindle pole body that is essential for microtubule function in Aspergillus nidulans.
Oakley BR, et al.
Cell, 61, 1289-1301 (1990)
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