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生物源
human
重組細胞
expressed in HEK 293 cells
籤條
6-His tagged (C-terminus)
化驗
≥95% (SDS-PAGE)
形狀
lyophilized
分子量
calculated mol wt 70.7 kDa
observed mol wt 85-90 kDa (DTT-reduced. Protein migrates due to glycosylation. Phe 22 is the predicted N-terminus.)
包裝
pkg of 10 μg
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... NRP1(8829)
一般說明
Neuropilin-1 (NRP1) is also known as vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The NRP1 gene is located on human chromosome 10p11.22.
生化／生理作用
Neuropilin-1 (NRP1) is membrane spanning protein that serves as coreceptor for a number of growth factors such as vascular endothelial growth factor, transforming growth factor β1, hepatocyte growth factor and platelet-derived growth factor. It is known to mediate immune responses, wound healing and angiogenesis, epithelial to mesenchymal transition in cancer. Mutation in the NRP1 gene results in tetralogy of Fallot (congenital heart disease).
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, tThe PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, tThe PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells
外觀
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
重構
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
The NRP1 migraine risk variant shows evidence of association with menstrual migraine.
Pollock C E, et al.
The Journal of Headache and Pain, 19(1), 31-31 (2018)
The Expression of neuropilin-1 in human placentas from normal and preeclamptic pregnancies.
Arad A, et al.
International Journal of Gynecological Pathology, 36(1), 42-49 (2017)
Neuropilin-1 is a receptor for extracellular miRNA and AGO2/miRNA complexes and mediates the internalization of miRNAs that modulate cell function.
Prud'homme G J, et al.
Oncotarget, 7(42), 68057-68057 (2016)
Functional polymorphisms of the neuropilin 1 gene are associated with the risk of tetralogy of Fallot in a Chinese Han population.
Fan S H, et al.
Gene, 653, 72-79 (2018)
L1 on ovarian carcinoma cells is a binding partner for Neuropilin-1 on mesothelial cells.
Stoeck A, et al.
Cancer Letters, 239(2), 212-226 (2006)
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