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P1588

Sigma-Aldrich

Placenta Growth Factor human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, powder, suitable for cell culture

别名:

PGF

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About This Item

MDL號碼:
MFCD00677685
分類程式碼代碼:
12352202
NACRES:
NA.77

product name

Placenta Growth Factor human, PlGF, recombinant, expressed in E. coli, powder, suitable for cell culture

生物源

human

品質等級

200

重組細胞

expressed in E. coli

化驗

≥95% (SDS-PAGE)

形狀

powder

品質

endotoxin tested

分子量

29 kDa

包裝

pkg of 10 and 50 μg

儲存條件

avoid repeated freeze/thaw cycles

技術

cell culture | mammalian: suitable

雜質

<1.0 EU/μg

運輸包裝

dry ice

儲存溫度

−70°C

相关类别

生化／生理作用

Placenta growth factor (PlGF) is expressed in the placenta and somewhat less in the heart, lung and thyroid gland. Placentally expressed PlGF may act as an autocrine on trophoblasts, which express both PlGF and its receptor (VEGFR-1). Since these cells also make VEGF-A, natural heterodimers (PlGF/VEGF-A) have also been detected. Two alternatively spliced isoforms of PlGF have been identified.

外觀

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.

準備報告

Recombinant human PlGF is lyophilized from a 0.2 micron filtered solution of 30% CH3CN and 0.1% TFA (pH 7.4) containing 50 microg of bovine serum albumin per 1 microg of cytokine.

重構

Reconstitute with sterile PBS containing at least 0.1% HSA or BSA. The rhP/GF concentration should be no less than 10 μg/mL.

分析報告

The biological activity is measured by the ability to bind rhFlt-1/Fc in a functional ELISA. Immobilized rhFlt-1/Fc at 2 μg/mL (100 μL/well) can bind rhP/GF with a linear range at 0.1 - 5 ng/mL.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Domenico Ribatti
Angiogenesis, 11(3), 215-221 (2008-06-24)
The placental growth factor (PlGF) is an angiogenic protein belonging to the vascular endothelial growth factor (VEGF) family, which was discovered in 1991 by an Italian scientist, Maria Graziella Persico. Dr Persico cloned and purified PlGF and determined its structure
Suk Ho Byeon et al.
Investigative ophthalmology & visual science, 51(2), 1190-1197 (2009-10-17)
Vascular endothelial cell growth factor (VEGF) is strongly induced by oxidative stress in retinal pigment epithelial (RPE) cells, and VEGF-A is a survival factor for various cell types. This study was conducted to determine whether the autocrine VEGF signaling pathway
Ai-Yi Zhou et al.
World journal of pediatrics : WJP, 10(3), 262-270 (2014-08-16)
Clinical trials have revealed that the antivascular endothelial growth factor (VEGF) therapies are effective in retinopathy of prematurity (ROP). But the low level of VEGF was necessary as a survival signal in healthy conditions, and endogenous placental growth factor (PIGF)
G Conn et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(4), 1323-1327 (1990-02-01)
A growth factor that is mitogenic for vascular endothelial cells, with an ED50 of approximately 1 ng/ml, has been purified 170,000-fold to apparent homogeneity from tissue culture medium conditioned by a rat glioma-derived cell line. The pure protein is a
Xu Zhou et al.
Scientific reports, 5, 10071-10071 (2015-05-12)
Cancer neovascularization plays an essential role in the metastasis of larynx carcinoma (LC). However, the underlying molecular mechanisms are not completely understood. Recently, we reported that placental growth factor (PLGF) regulates expression of matrix metalloproteinase 3 (MMP3) through ERK/MAPK signaling
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