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V3388

Vascular Endothelial Growth Factor (aa 207-318) human

Name: Vascular Endothelial Growth Factor (aa 207-318) human
Brand: SIGMA

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

别名:

VEGF₁₁₂, Vasculotropin

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About This Item

MDL號碼:

MFCD00286542

分類程式碼代碼:

12352202

NACRES:

NA.32

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Sigma-Aldrich

L9625

Leu-Gly

product name

Vascular Endothelial Growth Factor (aa 207-318) human, ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

生物源

human

品質等級

100

重組細胞

expressed in E. coli

化驗

≥97% (SDS-PAGE)

形狀

lyophilized powder

效力

0.75-3.75 ng/mL ED₅₀

分子量

predicted mol wt ~28 kDa

包裝

pkg of 5 μg

儲存條件

avoid repeated freeze/thaw cycles

雜質

<1 EU/μg

UniProt登錄號

P15692

儲存溫度

−20°C

基因資訊

human ... VEGFA(7422)

應用

Vascular Endothelial Growth Factor (aa 207-318) human also known as VEGF 121 was used for preparing a cellular matrix hybridized with hyaluronic acid (ACM-HA) VEGF constructs which is used in measuring the VEGF-enhanced tissue-engineered bladder graft neovascularization by using dynamic contrast-enhanced MRI. The product was used for creating VEGF-impregnated tissue-engineered construct which was inserted in the critical-sized calvarial defect in the membranous parietal bone of the rabbit for examining and characterizing the angiogenesis necessary for bone formation.

生化／生理作用

Vascular Endothelial Growth Factor (aa 207-318) human also referred to as VEGF 121 or Vasculotropin is a basic protein that induces endothelial cell growth, vasculogenesis and angiogenesis. VEGF also enhances the growth of endothelial cells isolated from cerebral cortex, fetal and adult aorta as well as human umbilical vein. Cells enhance VEGF 121 secretion from fibrin implants results in local and controlled blood vessel growth.

Potent angiogenesis inducer in vivo.

其他說明

112 amino acid residue variant of human VEGF.

外觀

Lyophilized from a 0.2 μm filtered solution in 30% acetronitrile and 0.1% TFA containing 0.25 mg bovine serum albumin.

分析報告

The biological activity is measured by its ability to stimulate ³H-thymidine incorporation in human umbilical vein endothelial cells.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Monitoring angiogenesis in soft-tissue engineered constructs for calvarium bone regeneration: an in vivo longitudinal DCE-MRI study.

Marine Beaumont et al.

NMR in biomedicine, 23(1), 48-55 (2009-08-04)

Tissue engineering is a promising technique for bone repair and can overcome the major drawbacks of conventional autogenous bone grafting. In this in vivo longitudinal study, we proposed a new tissue-engineering paradigm: inserting a biological soft-tissue construct within the bone

Dynamic contrast-enhanced MRI to quantify VEGF-enhanced tissue-engineered bladder graft neovascularization: pilot study.

Lisa Cartwright et al.

Journal of biomedical materials research. Part A, 77(2), 390-395 (2006-01-24)

Tissue engineered organs require an immediately perfused vascular tree. Currently, neovascularization assessment requires animal sacrifice and graft harvest. In this pilot study we assess whether neovascularization of an engineered urinary bladder construct is enhanced with vascular-derived endothelial growth factor (VEGF)

Leung, D.W., et al.

Science, 246 (1989)

Molecular and biological properties of the vascular endothelial growth factor family of proteins.

N Ferrara et al.

Endocrine reviews, 13(1), 18-32 (1992-02-01)

Cell-demanded liberation of VEGF121 from fibrin implants induces local and controlled blood vessel growth.

Martin Ehrbar et al.

Circulation research, 94(8), 1124-1132 (2004-03-27)

Although vascular endothelial growth factor (VEGF) has been described as a potent angiogenic stimulus, its application in therapy remains difficult: blood vessels formed by exposure to VEGF tend to be malformed and leaky. In nature, the principal form of VEGF

商品

Vascular Endothelial Growth Factors (VEGF)

Vascular endothelial growth factor (VEGF) is a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGF-A (VEGF) is a potent growth factor for blood vessel endothelial cells, showing pleiotropic responses that facilitate cell migration, proliferation, tube formation, and survival. In the developing embryo VEGF-A mRNA is expressed by cells within tissues undergoing capillarization.