推荐产品
产品名称
Vascular Endothelial Growth Factor 121 human, VEGF121, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
生物源
human
品質等級
重組細胞
expressed in HEK 293 cells
化驗
≥95% (SDS-PAGE)
形狀
lyophilized powder
效力
≤15 ng/mL EC50
品質
endotoxin tested
分子量
dimer 37 kDa (glycosylated)
trimer 50 kDa (glycosylated)
包裝
pkg of 10 μg
製造商／商標名
HumanZyme
儲存條件
avoid repeated freeze/thaw cycles
技術
cell culture | mammalian: suitable
雜質
≤1 EU/μg
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... VEGFA(7422)
一般說明
HumanPro VEGF-121(vascular endothelial growth factor 121) is an isoform of VEGFA and is expressed in human HEK 293 cells as a disulfide linked, glycosylated cytokine with an apparent molecular mass of 37 kDa as a homodimer and 50 kDa as a homotrimer. VEGF-A exists in three different isoforms VEGF-121, VEGF165 is an angiogenic properties. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
There are five types of VEGF ligands identified in mammals, which exists as different splice variants.VEGFA is a dimeric glycoprotein consisting two monomers antiparallel to each other.
There are five types of VEGF ligands identified in mammals, which exists as different splice variants.VEGFA is a dimeric glycoprotein consisting two monomers antiparallel to each other.
生化／生理作用
Vascular endothelial growth factor 121 (VEGF121) belongs to the PDGF/VEGF growth factor family. Many cell types secrete VEGF, and it is a potent angiogenic factor and mitogen that stimulates proliferation, migration, and formation of endothelial cells. VEGF stimulates permeabilization of blood vessels and is present in some tumors of the nervous system. VEGF is induced by hypoxia, oncogene mutations, and cytokines such as IL-1, IL-8, and TNF-α.
外觀
Lyophilized from a 0.2 μm filtered solution of 1X PBS
分析報告
The specific activity was determined by the dose-dependent stimulation of the proliferation of HUVEC cells (human umbilical vein endothelial cells).
法律資訊
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
VEGF121b and VEGF165b are weakly angiogenic isoforms of VEGF-A
Catena R, et al.
Molecular Cancer, 9.1 (2010)
Vascular endothelial growth factor stimulates osteoblastic differentiation of cultured human periosteal-derived cells expressing vascular endothelial growth factor receptors.
Hah YS, Jun JS, Lee SG
Molecular Biology Reports (2010)
Transcriptome-wide Landscape of Pre-mRNA
Alternative Splicing Associated with Metastatic Colonization
Alternative Splicing Associated with Metastatic Colonization
Lu ZX, et al.
Molecular Cancer Research (2014)
Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
Fukumura D, et al.
Proceedings of the National Academy of Sciences of the USA, 98.5, 2604-2609 (2001)
VEGF receptor signalling ? in control of vascular function
Olsson AK, et al.
Nature Reviews in Molecular and Cell Biology, 7.5 (2006)
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