SRP0300

TGF-β1 Latent human

recombinant, expressed in FreeStyle^™ 293-F cells, ≥98% (SDS-PAGE)

• 别名: LAP, TGFb1, TGFbeta1, latency-associated peptide, transforming growth factor beta-1
• 分類程式碼代碼: 12352202
• NACRES: NA.32

属性

• 生物源: human
• 重組細胞: expressed in FreeStyle^™ 293-F cells
• 化驗: ≥98% (SDS-PAGE)
• 形狀: aqueous solution
• 分子量: 25 kDa
• 包裝: pkg of 5 μg
• 製造商／商標名: Invitrogen
• 儲存條件: avoid repeated freeze/thaw cycles
• NCBI登錄號: NM_000660
• UniProt登錄號: Q14766
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... LTBP1(4052)

说明

一般說明

Human TGFβ1 (GenBank Accession No. NM_000660), amino acids 30-390 (end) with Cys33Ser mutation and N-terminal His-tag, disulfide-linked homodimers of TGFβ1 LAP and mature TGFβ1, MW= ~75kDa and 25kDa, under non-reducing conditions.
LTBP1 (latent transforming growth factor β binding protein 1) belongs to the LTBP family of proteins. The protein has 18 epidermal growth factor (EGF)-like repeats and four LTBP-like repeats. The gene is mapped to human chromosome 2p22.3.

應用

Useful for cell culture and for the study of signaling and apoptotic pathways.

生化／生理作用

LTBP1 (latent transforming growth factor β binding protein 1) is an extracellular matrix protein which also controls TGF-β (transforming growth factor β) bioavailability. LTBP1 is mainly responsible for the folding and secretion of TGF-β, thereby adding it to the extracellular matrix. It is a target of HTRA1 (high temperature requirement protein A1), a serine protease involved in cellular signaling.

外觀

Lyophilized from a 0.2 μM filtered, aqueous solution.

重構

Reconstitute in sterile PBS with 0.1% BSA. Stability: >6 months at –70°C (as a solid). Store reconstituted protein in aliquots at –80°C for up to 3 months. Avoid freeze/thaw cycles.

法律資訊

FreeStyle is a trademark of Invitrogen Corp.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable