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product name
转化生长因子-β1 人, TGF-β1, Xeno-free, recombinant, expressed in HEK 293 cells, suitable for cell culture
生物源
human
品質等級
重組細胞
expressed in HEK 293 cells
化驗
≥95% (SDS-PAGE)
形狀
lyophilized powder
效力
≤0.5 ng/mL EC50
品質
endotoxin tested
分子量
dimer 25 kDa (non-glycosylated)
包裝
pkg of 5 μg
儲存條件
avoid repeated freeze/thaw cycles
技術
cell culture | mammalian: suitable
雜質
≤1 EU/μg
UniProt登錄號
儲存溫度
-10 to -25°C
基因資訊
human ... TGFB1(7040)
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一般說明
The TGFB1 gene is mapped to human chromosome 19q13.2 and codes for a 25 kDa peptide. TGF-ß1 polypeptide is produced as a precursor with hydrophobic signal sequence, pro-region and mature peptide. Cleavage of the precursor at tetrabasic cleavage site results in monomers of carboxy-terminal 112 amino acids. The biologically active form of Tgfb1 exists as a disulphide-linked homodimer.
應用
Transforming Growth Factor-β1 (TGF-β) human has been used :
- to study the expression of PDGFRB (Platelet derived growth factor receptor β) in association with transforming growth factor-β signaling.
- to stimulate lung fibrosis in human fetal lung fibroblast cell line in order to further measure the in-plane elasticity of live cell layers using a pressure sensor embedded microfluidic device.
- to study the effect of TGF-β on HTRA1 (high-temperature requirement A1)-affected Wnt target genes.
生化／生理作用
TGF-β1 is a multifunctional peptide capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed as well as non-neoplastic tissues release transforming growth factors and essentially all cells possess a specific TGF-β1 receptor. In general, cells of mesenchymal origin appear to be stimulated by TGF-β1; whereas, hepatocytes, T and B lymphocytes, keratinocytes, and many epithelial cells are inhibited by the peptide. TGF-β1 interacts with Epidermal Growth Factor (EGF), Platelet Derived Growth Factor (PDGF), Fibroblast Growth Factor (FGF), and T Cell Growth Factor (T-CGF) either by enhancing or antagonizing their characteristic actions. TGF-β1 plays a fundamental role in tissue growth and differentiation by involvement in adipogenesis, myogenesis, chondrogenesis, osteogenesis, epithelial cell differentiation, and immune cell function. TGF-β1 is associated with the developmental and metastasis of colorectal cancer.
转化生长因子-β1 (TGF-β1)由多种细胞合成，但据报道，其含量在哺乳动物血小板中最丰富，约为TGF-β2浓度的四倍。
外觀
Lyophilized from a 0.2 μm filtered solution of 50 mM NaOAc pH 4.5
分析報告
The activity was determined by the dose dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).
訊號詞
Danger
危險聲明
危險分類
Eye Dam. 1 - Skin Corr. 1B
儲存類別代碼
8A - Combustible corrosive hazardous materials
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
High-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling
Globus O, et al.
Scientific Reports, 1-12 (2017)
Interplay between TGF-? signaling and receptor tyrosine kinases in tumor development.
Shi Q and Chen YG
Science China: Life Sciences, 60(10), 1133-1114 (2017)
TGF β signalling and its role in tumour pathogenesis
Kaminska B, et al.
Acta Biochimica Polonica, 52, 329-337 (2005)
Role of TGF-? in metastatic colon cancer: it is finally time for targeted therapy.
Villalba M, et al.
Cell and Tissue Research, 370(1), 29-39 (2017)
The transforming growth factor-?1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
Celedon JC, et al.
Human Molecular Genetics, 13, 1649-1656 (2004)
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