SML3861

Methoxy-X04

≥98% (HPLC)

• 别名: 4,4′-(1E,1′E)-2,2′-(2-Methoxy-1,4-phenylene)bis(ethene-2,1-diyl)diphenol, 4,4′-[(2-Methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol, MX04, MXO4, MeO-X04, MeO-XO4, MeX04, MeXO4, Methoxy-XO4, MethoxyX04, MethoxyXO4
• 经验公式（希尔记法）: C₂₃H₂₀O₃
• CAS号: 863918-78-9
• 分子量: 344.40
• MDL號碼: MFCD25563254
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: , Faint yellow to dark orange
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C

说明

生化／生理作用

Methoxy-X04 (MeO-X04, MethoxyX04, MeX04, MX04) is a blood-brain barrier-permeant fluorescent probe derived from the Chrysamine G and Congo red scaffold that retains affinity toward amyloid beta (Aβ) fibrils (Ki = 25.3 nM/Chrysamine G and 26.8 nM/Methoxy-X04), while being much more lipophilic than Chrysamine G and Congo red. Methoxy-X04 stains Aβ plaques, tangles, and cerebrovascular amyloid in postmortem brain sections with good specificity and is commonly utilized for high-resolution fluorescent imaging of individual amyloid plaques in live animals by 2-photon microscopy (Ex. 750-800 nm; Em. 380-480, 500-540, and 560-650 nm) following i.v. or i.p. injection (5-10 mg/kg).

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable