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SML3153

Sigma-Aldrich

AMG 487

≥98% (HPLC)

别名:

(R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]-pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxyphenyl)-acetamide, AMG-487, AMG487

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About This Item

经验公式（希尔记法）:
C32H28F3N5O4
CAS号:
473719-41-4
分子量:
603.59
MDL號碼:
MFCD30536209
分類程式碼代碼:
12352200
NACRES:
NA.51

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

FC(F)(F)Oc1ccc(cc1)CC(=O)N(Cc5cnccc5)C(=C2Nc3ncccc3C(=O)N2c4ccc(cc4)OCC)C

InChI

1S/C32H28F3N5O4/c1-3-43-25-14-10-24(11-15-25)40-30(38-29-27(31(40)42)7-5-17-37-29)21(2)39(20-23-6-4-16-36-19-23)28(41)18-22-8-12-26(13-9-22)44-32(33,34)35/h4-17,19H,3,18,20H2,1-2H3,(H,37,38)

InChI 密鑰

IEKPMGNVFDUVPK-UHFFFAOYSA-N

生化／生理作用

AMG 487 is an orally available, potent and selective chemokine (C-X-C motif) receptor 3 (CXCR3) antagonist (IC50 = 8/8.2 nM against CXCL10/11 (IP-10/ITAC) for CXCR3 binding) that inhibits CXCR3 ligands-induced cell migration (CXCL10/11/9 IC50 = 8/15/36 nM). AMG 487 inhibits ITAC-induced calcium mobilization in vitro (IC50 = 5 nM) and reduces bleomycin-induced cellular lung recruitment in wild-type mice to the same level as in Cxcr3-deficient mice in vivo (3 mg/kg b.i.d. s.c.).
Orally available, potent and selective chemokine (C-X-C motif) receptor 3 (CXCR3) antagonist in vitro and in vivo.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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