SML0849

GKA50

≥98% (HPLC)

• 别名: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]-3-pyridinecarboxylic acid
• 经验公式（希尔记法）: C₂₆H₂₈N₂O₆
• CAS号: 851884-87-2
• 分子量: 464.51
• 分類程式碼代碼: 51111800
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 15 mg/mL, clear
• 儲存溫度: −20°C
• InChI: 1S/C26H28N2O6/c1-17(11-19-7-5-4-6-8-19)33-22-12-21(13-23(14-22)34-18(2)16-32-3)25(29)28-24-10-9-20(15-27-24)26(30)31/h4-10,12-15,17-18H,11,16H2,1-3H3,(H,30,31)(H,27,28,29)/t17-,18-/m0/s1
• InChI 密鑰: OCBMECSFDVUYQN-ROUUACIJSA-N

说明

生化／生理作用

GKA50 is a specific activator of glucokinase (EC₅₀ = 0.03 μM). In mouse MIN6 insulin-secreting cells and rat pancreatic islet cells, GKA50 elicits a leftward shift in response to sub-maximal glucose concentrations as measured by insulin secretion and elevation of intracellular calcium levels.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H413
• 防範說明: P273 - P301 + P312 + P330
• 危險分類: Acute Tox. 4 Oral - Aquatic Chronic 4
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable