SML1637

Hexaminolevulinate hydrochloride

≥98% (HPLC)

• 别名: 5-Aminolevulinic acid hexyl ester HAL hydrochloride, 5-Aminolevulinic acid hexyl ester hydrochloride, HAL, Hexvix, Hexyl 5-aminolevulinate hydrochloride, P 1206, n-Hexyl 5-aminolevulinate hydrochloride
• 经验公式（希尔记法）: C₁₁H₂₁NO₃ · HCl
• CAS号: 140898-91-5
• 分子量: 251.75
• MDL號碼: MFCD03695491
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825978

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to beige
• 溶解度: H₂O: 20 mg/mL, clear
• 儲存溫度: room temp
• SMILES 字串: CCCCCCOC(CCC(CN)=O)=O.[H]Cl
• InChI: 1S/C11H21NO3.ClH/c1-2-3-4-5-8-15-11(14)7-6-10(13)9-12;/h2-9,12H2,1H3;1H
• InChI 密鑰: LZYXPFZBAZTOCH-UHFFFAOYSA-N

说明

生化／生理作用

Hexaminolevulinate (HAL) hydrochloride is a hexyl ester of 5-Aminolevulinic acid (ALA), a precursor to porphyrins including the photosensitizer protoporphyrin IX (PPIX). Hexaminolevulinate is more lipophilic than ALA, and is 50–100 times more efficient than ALA at inducing PpIX, which accumulates preferentially in neoplastic cells. Hexaminolevulinate administration followed by light activation has been used for fluorescence cystoscopy to enhance detection of bladder cancer, in particular carcinoma in situ (CIS). Hexaminolevulinate is also being studied for use in cancer photodynamic therapy. Hexaminolevulinate followed by irradiation produced DNA oxidative damage and apoptosis.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3