推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
room temp
SMILES 字串
CC(C(O)=O)c1ccc(cc1)C(=O)c2cccs2
InChI
1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
InChI 密鑰
MDKGKXOCJGEUJW-UHFFFAOYSA-N
基因資訊
human ... PTGS1(5742) , PTGS2(5743)
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應用
Suprofen has been used to evaluate the combination of trifluoroacetic acid and isopropylamine (IPA) in supercritical fluid chromatography. It has also been used to evaluate immobilized chiral polysaccharide-based stationary phases in supercritical fluid chromatography.
生化／生理作用
Suprofen is a nonsteroidal anti-inflammatory drug that inhibits COX-1/2. Suprofen exhibits a potent anti-inflammatory, analgesic and antipyretic activities.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
A S Nies
Agents and actions. Supplements, 24, 95-106 (1988-01-01)
All nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase, and consequently renal functions dependent upon prostaglandin synthesis can be affected. Fortunately, renal function in normal individuals is relatively independent of the PG system, and thus the NSAIDs don't usually produce any renal
Pharmaceutical-enantiomers resolution using immobilized polysaccharide-based chiral stationary phases in supercritical fluid chromatography
De Klerck
Journal of Chromatography A (2014)
C J Niemegeers et al.
Arzneimittel-Forschung, 25(10), 1505-1509 (1975-10-01)
A new standardized acetic acid-induced writhing test in rats is described in detail and its methodology is discussed briefly. The described method has proved to be useful for evaluating the anti-writhing activity of narcotic analgesics, non-narcotic anti-inflammatory compounds and narcotic-antagonists
R J Capetola et al.
The Journal of pharmacology and experimental therapeutics, 214(1), 16-23 (1980-07-01)
The antinociceptive properties of suprofen [alpha-methyl-4-(thienylcarbonyl)benzene acetic acid] are described in a pathologically induced hyperalgesic model, the rat adjuvant arthritis flexion test. By using this assay, suprofen was characterized as an orally effective, non-narcotic analgesic with a rapid onset and
Malin Darnell et al.
Chemical research in toxicology, 28(5), 886-896 (2015-03-25)
Xenobiotic carboxylic acids may be metabolized to oxidative metabolites, acyl glucuronides, and/or S-acyl-CoA thioesters (CoA conjugates) in vitro, e.g., in hepatocytes, and in vivo. These metabolites can potentially be reactive species and bind covalently to tissue proteins and are generally
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