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應用
小豆蔻明已被用作糖原合酶激酶3（GSK3）抑制剂，用于研究其对植入前人胚胎中β-连环蛋白功能缺失和获得（loss and gain-of-function）的影响。
小豆蔻明已被用作高效液相色谱（HPLC）分析金合欢（acacia）蜂蜜样品中酚类化合物中的标准品。
生化／生理作用
小豆蔻醚 (Cardamonin) 是一种来自豆蔻属（姜科植物）的植物。小豆蔻醚通过抑制 Wnt/β-连环蛋白 信号通路抑制黑素细胞色素沉着。小豆蔻醚通过蛋白酶体介导降解 β-连环蛋白（GSK-3β 非依赖性途径）抑制 Wnt/β-连环蛋白信号通路。研究表明，小豆蔻醚通过抑制 NF-kB 核转位和 Ik-Ba 磷酸化而具有抗炎活性。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Peiguang Niu et al.
Oncology letters, 15(3), 3991-3997 (2018-02-20)
The mammalian target of rapamycin (mTOR) is well-known as a promising therapeutic target in various cancer cells. mTOR activation decreases the sensitivity of ovarian cancer to cisplatin. Cardamonin inhibits the proliferation of various cancer cells by mTOR suppression. The present
Ning Wu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(12), 9667-9676 (2015-07-08)
Glioblastoma stem cells (GSCs) are the initiating cells in glioblastoma multiforme (GBM) and contribute to the resistance of GBM to chemotherapy and radiation. In the present study, we investigated the effects of cardamonin (3,4,2,4-tetrahydroxychalcone) on the self-renewal and apoptosis of
Sen Lu et al.
Oncology letters, 15(6), 9641-9646 (2018-06-22)
It has previously been reported that cardamonin is able to regulate glycometabolism and vasodilation whilst also exhibiting anti-inflammatory and antitumor properties. The antitumor effect of cardamonin is multifaceted, and so it is necessary to investigate the antitumor mechanisms of cardamonin
Sudesh Pawaria et al.
PloS one, 7(11), e50365-e50365 (2012-12-12)
The cell surface receptor CD91/LRP-1 binds to immunogenic heat shock proteins (HSP) and α(2)M ligands to elicit T cell immune responses. In order to generate specific immune responses, the peptides chaperoned by HSPs or α(2)M are cross-presented on MHC molecules
Hyun Dong Je et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 20(1), 69-74 (2016-01-26)
The present study was undertaken to investigate the influence of cardamonin on vascular smooth muscle contractility and to determine the mechanism(s) involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments.
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