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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
NC(NC(C1=CC(S(C)(=O)=O)=C(C(C)C)C=C1)=O)=N
InChI
1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16)
InChI 密鑰
IWXNYAIICFKCTM-UHFFFAOYSA-N
生化／生理作用
卡立泊来德是 Na +/H + 交换子亚型 1 (NHE-1) 的选择性抑制剂，也称为 Na +/H + 逆向转运蛋白。卡立泊来德已显示出心脏保护和抗心律失常作用，最近对其抗癌活性进行了研究。
卡立泊来德是一种钠氢交换抑制剂 ，可减少缺血/再灌注时肌红蛋白的释放，减少缺血时 NE（去甲肾上腺素）的释放。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Zhuoqun Fang et al.
Shock (Augusta, Ga.), 54(6), 819-827 (2020-06-05)
Na/H exchanger 1 (NHE1) is a ubiquitously expressed protein on mammalian plasma membranes and involved in cell apoptosis and tissue injury. Our previous study found that NHE1 inhibition prevents burn-induced acute lung injury (ALI). However, the potential mechanism of NHE1
Jair C Kwan et al.
Heart, lung & circulation, 24(3), 306-318 (2014-12-03)
Storage of donor hearts in cardioplegic solutions supplemented with agents that mimic the ischaemic preconditioning response enhanced their post-reperfusion function. The present study examines the minimisation of cell death and activation of pro-survival signalling directed towards maintenance of mitochondrial homeostasis
Shigeru Sakurai et al.
Life sciences, 114(2), 102-106 (2014-08-21)
To examine the effects of cariporide, a Na(+)/H(+) exchanger-1 inhibitor, on cardiac norepinephrine (NE) and myoglobin release during myocardial ischemia/reperfusion by applying a microdialysis technique to the rabbit heart. In anesthetized rabbits, two dialysis probes were implanted into the left
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