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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear (warmed)
儲存溫度
2-8°C
InChI
1S/C19H15NO3S/c1-14-10-12-15(13-11-14)24(21,22)20-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)20/h2-13H,1H3
InChI 密鑰
DHZNMEIBMACSFH-UHFFFAOYSA-N
應用
PSB-12062 has been used as a P2X4 antagonist to pre-treat macrophages in inhibitor screening studies to understand the inflammation process. It has also been used as P2X4 antagonists to pre-treat P2X7-deficient BV-2 cells to elucidate the roles of P2X4.
生化／生理作用
PSB-12062 is a P2X4 receptor antagonist. P2X4 receptors are highly expressed in the central nervous system (CNS), and have been studied as a therapeutic target for neutopathic pain, and treatment of traumatic brain injury, cerebral ischemia, and spinal cord injury. PBS-12062 is a new P2X4-specific antagonist with equal potency against human, rat and mouse receptors (IC50s 1.38, 0.92 and 1.76 μM, respecitively). The compound does not display significant inhibition of human P2X1, P2X2, P2X3 or P2X7 at 10 μM.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Chronic 4
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Stefan Uderhardt et al.
Cell, 177(3), 541-555 (2019-04-09)
Neutrophils are attracted to and generate dense swarms at sites of cell damage in diverse tissues, often extending the local disruption of organ architecture produced by the initial insult. Whether the inflammatory damage resulting from such neutrophil accumulation is an
Kshitija Dhuna et al.
Molecular pharmacology, 95(2), 210-221 (2018-12-14)
We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allosteric modulators on P2X receptors. ATP-induced responses were measured in stable cell lines overexpressing human P2X4 using a YOPRO-1 dye uptake assay, intracellular calcium measurements, and whole-cell
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