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Merck
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SML0450

Sigma-Aldrich

5-BDBD

≥98% (HPLC)

别名:

5-（3-溴苯基）-1,3-二氢-2H-苯并呋喃并[3,2-E] -1,4-二氮杂-2-酮

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About This Item

经验公式（希尔记法）:
C17H11BrN2O2
CAS号:
768404-03-1
分子量:
355.19
MDL號碼:
MFCD18086878
分類程式碼代碼:
12352200
PubChem物質ID:
329824730
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 15 mg/mL (clear solution)

儲存溫度

2-8°C

SMILES 字串

Brc1cccc(c1)C2=NCC(=O)Nc3c2oc4ccccc34

InChI

1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)

InChI 密鑰

NKYMVQPXXTZHSF-UHFFFAOYSA-N

生化／生理作用

5-BDBD 是 P2X4 的特异性抑制剂。该化合物抑制 CHO 细胞中的 P2X4 电流，IC50 为 500nM。
在天然组织中，5-BDBD被认为是分析P2X受体（P2XRs）亚型P2X4R作用的有益拮抗剂。

特點和優勢

该化合物的相关信息整理于受体分类和信号转导手册的 P2受体：P2X离子通道家族 页面。欲浏览其他手册页面，请 点击这里。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
082M4609V

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Yucui Jiang et al.
Journal of inflammation research, 14, 2913-2931 (2021-07-10)
Mast cells are well known for their role in inflammatory pain. P2X7 receptor (P2X7R) has attracted much attention due to its prominent role in inflammatory diseases. Salicylates are commonly used anti-inflammatory and analgesic drugs. Until now, little has been known
Hyuck Joon Kwon et al.
Scientific reports, 6, 39302-39302 (2016-12-23)
Electrical stimulation (ES) is known to guide the development and regeneration of many tissues. However, although preclinical and clinical studies have demonstrated superior effects of ES on cartilage repair, the effects of ES on chondrogenesis remain elusive. Since mesenchyme stem
Janice A Layhadi et al.
International journal of molecular sciences, 20(20) (2019-10-18)
Tissues differentially secrete multiple colony stimulating factors under conditions of homeostasis and inflammation, orientating recruited circulating monocytes to differentiate to macrophage with differing functional phenotypes. Here, we investigated ATP-evoked intracellular Ca2+ responses in human macrophage differentiated with macrophage colony-stimulating factor
Claudio Coddou et al.
Neuroscience letters, 690, 219-224 (2018-10-27)
P2X receptors (P2XRs) are a family of ATP-gated ionic channels that are expressed in numerous excitable and non-excitable cells. Despite the great advance on the structure and function of these receptors in the last decades, there is still lack of
Andreas Zech et al.
Oncotarget, 7(49), 80288-80297 (2016-11-20)
Compelling evidences point out a crucial role for extracellular nucleotides such as adenosine triphosphate (ATP) during inflammatory conditions. Once released into the extracellular space, ATP modulates migration, maturation and function of various inflammatory cells via activating of purinergic receptors of
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