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Merck

SML0430

Sigma-Aldrich

PR-619

≥95% (HPLC)

别名:

2,6-二氨基-3,5-二硫氰基吡啶, 硫氰酸 C,C′-(2,6-二氨基-3,5-吡啶二基)酯;2,6-二氨基吡啶-3,5-双(硫氰酸酯)

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About This Item

经验公式(希尔记法):
C7H5N5S2
CAS号:
分子量:
223.28
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥95% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 5 mg/mL (clear solution)

儲存溫度

−20°C

SMILES 字串

Nc1nc(N)c(SC#N)cc1SC#N

InChI

1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)

InChI 密鑰

ZXOBLNBVNROVLC-UHFFFAOYSA-N

應用

PR-619已被用于:
  • 作为裂解缓冲液的成分,以及用作去泛素化酶抑制剂用于处理来源于SILAC-标记Jurkat 细胞的蛋白质
  • 作为去泛素化酶抑制剂用于研究其对腺相关病毒 (AAV) 转导的影响
  • 用于泛素化检测用放射免疫沉淀测定缓冲液 (RIPA)

生化/生理作用

PR-619 是一种细胞可透过性广谱去泛素化酶(DBUs)抑制剂。PR-619 在不直接影响蛋白酶体活性的情况下,诱导细胞中多泛素化蛋白质的积聚。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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Large-scale identification of ubiquitination sites by mass spectrometry
Udeshi ND, et al.
Nature Protocols, 8(10), 1950-1950 (2013)
Tyler Bland et al.
Endocrinology, 160(8), 1982-1998 (2019-06-15)
Leptin has neurotrophic actions in the hippocampus to increase synapse formation and stimulate neuronal plasticity. Leptin also enhances cognition and has antidepressive and anxiolytic-like effects, two hippocampal-dependent behaviors. In contrast, mice lacking leptin or the long form of the leptin
Cytosolic iron-sulfur assembly is evolutionarily tuned by a cancer-amplified ubiquitin ligase
Weon JL, et sl.
Molecular Cell, 69(1), 113-125 (2018)
Anne Garreau et al.
Journal of immunology (Baltimore, Md. : 1950), 199(8), 2758-2766 (2017-09-08)
Themis is a new component of the TCR signaling machinery that plays a critical role during T cell development. The positive selection of immature CD4
Yang Wang et al.
Animal reproduction science, 187, 64-73 (2017-10-17)
This study was undertaken to investigate the dynamics of protein ubiquitination in pig gametes and their micro-environments, as well as to explore the action of deubiquitinases (DUBs) in sperm-oocyte binding. Protein ubiquitination states were evaluated by in the ejaculated sperm

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