推荐产品
产品名称
ALLN, Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).
品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
顏色
white to off-white
溶解度
DMSO: 10 mg/mL
ethanol: 5 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
InChI 密鑰
FMYKJLXRRQTBOR-BZSNNMDCSA-N
一般說明
钙蛋白酶I（Ki=190 nM），钙蛋白酶II（Ki=220 nM），组织蛋白酶B（Ki=150 nM）和组织蛋白酶L（Ki=500 pM）的抑制剂。抑制中性半胱氨酸蛋白酶和蛋白酶体（Ki = 6 µM）。防止缺氧和缺血引起的神经元损伤。抑制胸腺细胞和晚幼粒细胞中的凋亡。通过抑制细胞周期蛋白B降解，抑制CHO细胞中G1/S边界和中期/后期的细胞周期进程。还可以通过干扰诱导型一氧化氮合酶基因的转录来防止活化巨噬细胞产生一氧化氮。抑制泛素-蛋白酶体复合物对IκBα和IκBβ的蛋白水解作用。
钙蛋白酶I（Ki=190 nM），钙蛋白酶II（Ki=220 nM），组织蛋白酶B（Ki=150 nM）和组织蛋白酶L（Ki=500 pM）的细胞可渗透抑制剂。抑制中性半胱氨酸蛋白酶和蛋白酶体（Ki = 6 µM）。调节β-淀粉样前体蛋白（βAPP）至β-淀粉样蛋白（Aβ）的加工。防止缺氧和缺血引起的神经元损伤。抑制胸腺细胞和晚幼粒细胞中的凋亡。还抑制L929细胞中呼肠孤病毒诱导的凋亡。抑制泛素-蛋白酶体复合物对IκBα和IκBβ的蛋白水解作用。通过抑制细胞周期蛋白B降解，抑制CHO细胞G1/S和中期/后期的细胞周期进程。还可以通过干扰诱导型一氧化氮合酶基因的转录来防止活化巨噬细胞产生一氧化氮。也可购买10 mM（5 mg/1.30 ml）ALLN的DMSO溶液（目录号208750）。
生化／生理作用
针对钙蛋白酶I、钙蛋白酶II、组织蛋白酶B和组织蛋白酶L分别为190 nM、220 nM、150 nM、500 pM
主要靶标
钙蛋白酶I
钙蛋白酶I
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
警告
毒性：标准处理（A）
序列
N-Acetyl-Leu-Leu-Nle-CHO
重構
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。
其他說明
Debiasi, R.L., et al. 1999.J. Virol.73, 695.
Zhang, L., et al. 1999.J. Biol. Chem.274, 8966.
Milligan, S.A., et al. 1996.Arch.Biochem.Biophys.335, 388.
Griscavage, J.M., et al. 1995.Biochem.Biophys.Res. Commun.215, 721.
Squier, M.K., et al. 1994.J. Cell Physiol.159, 229.
Rami, J., and Kreiglstein, J. 1993.Brain Res.609, 67.
Sherwood, S.W., et al. 1993.Proc.Natl.Acad.Sci.USA90, 3353.
Vinitsky, A., et al. 1992.Biochemistry31, 9421.
Sasaki, T., et al. 1990.J. Enzyme Inhib.3, 195.
Zhang, L., et al. 1999.J. Biol. Chem.274, 8966.
Milligan, S.A., et al. 1996.Arch.Biochem.Biophys.335, 388.
Griscavage, J.M., et al. 1995.Biochem.Biophys.Res. Commun.215, 721.
Squier, M.K., et al. 1994.J. Cell Physiol.159, 229.
Rami, J., and Kreiglstein, J. 1993.Brain Res.609, 67.
Sherwood, S.W., et al. 1993.Proc.Natl.Acad.Sci.USA90, 3353.
Vinitsky, A., et al. 1992.Biochemistry31, 9421.
Sasaki, T., et al. 1990.J. Enzyme Inhib.3, 195.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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