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Merck

SML0324

Sigma-Aldrich

JW67

≥98% (HPLC)

别名:

Trispiro[3H-indole-3,2′-[1,3]dioxane-5′,5′′-[1,3]dioxane-2′′,3′′′-[3H]indole]-2,2′′′(1H,1′′′H)-dione (9CI)

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About This Item

经验公式(希尔记法):
C21H18N2O6
分子量:
394.38
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: >5 mg/mL

儲存溫度

2-8°C

SMILES 字串

O=C1Nc2ccccc2C13OCC4(CO3)COC5(OC4)C(=O)Nc6ccccc56

InChI

1S/C21H18N2O6/c24-17-20(13-5-1-3-7-15(13)22-17)26-9-19(10-27-20)11-28-21(29-12-19)14-6-2-4-8-16(14)23-18(21)25/h1-8H,9-12H2,(H,22,24)(H,23,25)

InChI 密鑰

BTXRSHKJNDFHGA-UHFFFAOYSA-N

生化/生理作用

JW67 is an efficient and specific inhibitor of the canonical Wnt signaling in vitro and in vivo. It appears that JW67 affects the multiprotein complex consisting of β-catenin/GSK-3b/AXIN/APC/CK1 that controls the degradation of β-catenin. JW67 reduces growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S phase.

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

防範說明

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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