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About This Item
经验公式（希尔记法）:
CH3BNa2O2
CAS号:
分子量:
103.82
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥95% (NMR)
形狀
powder
儲存條件
desiccated
顏色
white to beige
溶解度
H2O: >15 mg/mL
儲存溫度
room temp
SMILES 字串
[Na+].[Na+].[BH3-]C([O-])=O
InChI
1S/CH4BO2.2Na/c2-1(3)4;;/h2H3,(H,3,4);;/q-1;2*+1/p-1
InChI 密鑰
SOFPSQNQOQPAAJ-UHFFFAOYSA-M
應用
CORM-A1可用于：
- 提供一氧化碳（CO）并测试其在酵母和原代星形胶质细胞培养基中氧化应激时的细胞保护作用
- 作为小鼠巨噬细胞 J774A.1 中的 CO 供体，以测试其对细胞内啡呔升高的影响β
- 测试其对视网膜神经节细胞自噬激活的影响
生化／生理作用
CORM-A1是一种水溶性一氧化碳（CO）释放分子，可用于研究CO对细胞系统的影响。一氧化碳（CO）是在血红素加氧酶降解血红素过程中产生的一种重要的气体信号调节因子。CORM-A1在哺乳动物细胞中具有抗氧化和抗炎作用。
它以 pH 值和随温度变化的方式介导 CO 的释放，进而缓解轻度血管舒张和低血压。在氧化应激过程中，CORM-A1 可在星形胶质细胞原代培养基中提供细胞保护。这种含硼的 CORM 可促进自噬作用。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Kapil K Upadhyay et al.
Redox biology, 28, 101314-101314 (2019-09-13)
Nuclear factor-erythroid 2 related factor 2 (Nrf2)-mediated signaling plays a central role in maintaining cellular redox homeostasis of hepatic cells. Carbon monoxide releasing molecule-A1 (CORM-A1) has been reported to stimulate up-regulation and nuclear translocation of Nrf2 in hepatocytes. However, the
Helena Parfenova et al.
American journal of physiology. Heart and circulatory physiology, 315(4), H978-H988 (2018-07-22)
Neonatal asphyxia leads to cerebrovascular disease and neurological complications via a mechanism that may involve oxidative stress. Carbon monoxide (CO) is an antioxidant messenger produced via a heme oxygenase (HO)-catalyzed reaction. Cortical astrocytes are the major cells in the brain
Kapil K Upadhyay et al.
Toxicology and applied pharmacology, 360, 99-108 (2018-10-03)
Acute liver injury is frequently associated with oxidative stress. Here, we investigated the therapeutic potential of carbon monoxide releasing molecule A-1 (CORM A-1) in oxidative stress-mediated liver injury. Overnight-fasted mice were injected with acetaminophen (APAP; 300 mg/kg; intraperitoneally) and were sacrificed
Rui-Gang Zhang et al.
Molecular immunology, 105, 205-212 (2018-12-16)
Carbon monoxide (CO) is an anti-inflammatory gaseous molecule produced endogenously by heme oxygenases (HOs) HO-1 and HO-2. However, the mechanisms underlying the anti-inflammatory effects of CO in the human bronchial epithelium are still not fully understood. In this study, the
Myrna Constantin et al.
International journal of hypertension, 2012, 859235-859235 (2012-04-21)
Heme oxygenase (HO), a catabolic enzyme, provides the rate-limiting step in the oxidative breakdown of heme, to generate carbon monoxide (CO), iron, and biliverdin-IXα. Induction of the inducible form, HO-1, in tissues is generally regarded as a protective mechanism. Over
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