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描述
The structure of BV02 differs slightly from the published form, but has been internally verified by Sigma-Aldrich quality control.
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to off-white
溶解度
DMSO: >5 mg/mL
儲存溫度
room temp
SMILES 字串
CN1N(c2ccccc2)C(=O)C(N3C(=O)c4ccc(cc4C3=O)C(O)=O)=C1C
InChI
1S/C20H15N3O5/c1-11-16(19(26)23(21(11)2)13-6-4-3-5-7-13)22-17(24)14-9-8-12(20(27)28)10-15(14)18(22)25/h3-10H,1-2H3,(H,27,28)
InChI 密鑰
ZFYSDSINNOLWGO-UHFFFAOYSA-N
應用
BV02已被用于研究14-3-3σ对P-糖蛋白和孕烷X受体蛋白表达的影响。它还作为对照被用于研究BAP1（BRCA1（乳腺癌基因）相关蛋白1）通过与神经母细胞瘤中14-3-3的相互作用而诱导的细胞死亡。
BV02是14-3-3支架蛋白对接位点的一种抑制剂，可用于研究14-3-3支架蛋白在参与到细胞周期的信号通路以及诸如凋亡、应激反应和恶性细胞转化等过程中的作用和功能。
生化／生理作用
BV02是14-3-3支架蛋白对接位点的一种抑制剂。BV02可促进表达wt Bcr-Abl构建体或T315I突变的细胞凋亡性死亡。它可通过从14-3-3?释放的c-Abl诱导细胞凋亡，并重新定位到核室和线粒体膜。
訊號詞
Warning
危險聲明
危險分類
Aquatic Acute 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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