推荐产品
生物源
mouse
品質等級
共軛
peroxidase conjugate
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
HP-6025, monoclonal
形狀
lyophilized powder
物種活性
human
濃度
~2 mg/mL
技術
ELISA: 1:80,000-1:160,000 using 1 μg/mL human IgG4 for coating
同型
IgG1
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
一般說明
人IgG由四个亚类（1-4）组成，可通过它们的重链中的抗原差异进行识别。它们分别组成了约65、30、5和4%的总IgG。每个亚类都有不同干的生物和物理化学特性。IgG亚类可响应于不同的抗原和病理状况而被优先生成。只有IgG1和IgG3能够粘附于单核吞噬细胞，而IgG2和IgG4自身抗体与诸如溶血性贫血等疾病并无关联。不同患者组的血清IgG亚类缺陷已被记录。例如，在共济失调性毛细血管扩张症患者中发现IgG2和IgG4缺乏与IgA缺乏相关。对不同类型疾病中IgG亚类分布模式的检查可为所涉及的免疫过程提供洞察，从而助力于各种疾病的诊断。例如，疟疾患者中的IgG亚类表达模式揭示了IgG4水平与疟疾抗原之间的正相关，但与患者年龄却并无关联。抗-人IgG4单克隆抗体可特异性识别人IgG4。该抗体与IgG1、IgG2和IgG3并未显示出交叉反应性。IUIS/WHO研究将该单克隆抗体评估为应用最广泛的IgG4特异性单克隆抗体之一
免疫原
纯化的人IgG4骨髓瘤蛋白与聚氨基苯乙烯（PAS）微珠共价偶联
應用
该抗体可用于各种免疫化学技术，包括ELISA。
外觀
以冻干粉形式提供。用0.25 mL蒸馏水重悬至最终抗体浓度为∼2 mg / mL后，溶液在0.01 M磷酸钠缓冲盐水中包含1％BSA、2.5％海藻糖、0.05％MIT
其他說明
用0.25 ml蒸馏水重悬小管中的内容物，使最终抗体浓度为∼2 mg/ml。
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訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
P Aucouturier et al.
Clinical and experimental immunology, 68(2), 392-396 (1987-05-01)
Serum IgG subclass levels were determined using a competitive indirect immunoenzymatic assay with monoclonal antibodies in 16 patients with ataxia-telangiectasia. Eight children had IgA deficiency, two had IgG and IgA deficiency and six patients showed no immunoglobulin class abnormality. However
A Nasr et al.
Scandinavian journal of immunology, 74(4), 390-396 (2011-06-08)
The anti-malarial IgG immune response during the lengthy and dry season in areas of low malaria transmission as in Eastern Sudan is largely unknown. In this study, ELISA was used for the measurement of pre-existing total IgG and IgG subclasses
J D Isaacs et al.
Clinical and experimental immunology, 106(3), 427-433 (1996-12-01)
It is traditionally held that human IgG4 MoAbs should not deplete target cells in vivo, as this isotype is inactive in a number of in vitro assays that measure effector function. We have previously challenged this dogma, and the current
F W van der Meulen et al.
British journal of haematology, 46(1), 47-56 (1980-09-01)
The purpose of this study was to determine whether quantitative or qualitative factors are of major importance in the destruction of red cells sensitized with incomplete warm autoantibodies of subclass IgG1. To that end, the relative amount of igG1 antibody
R Jefferis et al.
Immunology letters, 10(3-4), 223-252 (1985-01-01)
Seventy-four monoclonal antibodies (McAb) of putative specificity for human IgG (11), the IgG sub-classes (59) or Gm allotypes (4) have been evaluated for reactivity and specificity in eight laboratories employing different assay techniques or protocols. For the IgG, IgG3, IgG4
商品
Antibody-based serology tests are useful in identifying subjects with an adaptive immune response to the SARS-CoV-2 virus. Anti-human immunoglobulin antibodies allow for quick and simple, yet reliable assays with easy readouts and can also be adapted for high-throughput screening.
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