推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
99998 Da
物種活性
hamster
物種活性(以同源性預測)
mouse
技術
immunohistochemistry: 1:500-1:1000
western blot: 1:1000
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... LGR5(8549)
一般說明
R-spondin受体增强经典Wnt信号通路,并可作为肠上皮和毛囊的干细胞标志物。结合R-spondin(RSPO1、RSPO2、RSPO3或RSPO4)后,它与磷酸化LRP6和卷曲受体(frizzled )结合,卷曲受体由胞外Wnt受体激活,从而引发经典Wnt信号通路以增加靶基因的表达。与经典G 蛋白偶联受体相比,它不会激活杂三聚体G蛋白以转导信号。参与胚后发育过程中成年肠肝细胞的发育和/或维护。在骨骼肌、胎盘、脊髓和大脑各区域中表达。在结肠和小粘膜干细胞的隐窝基底(base of crypt)中表达。癌前表达不限于隐窝基底。在卵巢、结肠和肝癌中过度表达。
外觀
纯化的单克隆抗体是含有0.09%(W/V)叠氮化钠的PBS溶液该抗体通过蛋白A柱以及随后的肽亲和纯化进行纯化。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類(WGK)
nwg
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Molecular cancer, 9, 212-212 (2010-08-10)
Recent evidence suggests that epithelial cancers, including colorectal cancer are driven by a small sub-population of self-renewing, multi-potent cells termed cancer stem cells (CSCs) which are thought to be responsible for recurrence of cancer. One of the characteristics of CSCs
PLoS genetics, 8(11), e1003048-e1003048 (2012-11-13)
Defining master transcription factors governing somatic and cancer stem cell identity is an important goal. Here we show that the Oct4 paralog Oct1, a transcription factor implicated in stress responses, metabolic control, and poised transcription states, regulates normal and pathologic
Cellular and molecular neurobiology, 30(3), 415-426 (2009-10-09)
Neural stem cells (NSC) with self-renewal and multipotent properties serve as an ideal cell source for transplantation to treat spinal cord injury, stroke, and neurodegenerative diseases. To efficiently induce neuronal lineage cells from NSC for neuron replacement therapy, we should
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