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生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
4F4, monoclonal
形狀
buffered aqueous solution
分子量
antigen 41 kDa
antigen 43 kDa
物種活性
monkey, human, chicken, hamster
技術
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.1-0.2 μg/mL using HeLa cell nuclear extract
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... HNRNPC(3183)
一般說明
Monoclonal Anti-hnRNP-C1/C2 (mouse IgG1isotype) is derived from the 4F4 hybridoma produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from BALB/c mice immunized with RNPs eluted from oligo (dT) cellulose column. Heterogeneous nuclear ribonucleoproteins C1/C2 (HnRNP C1/C2) are synthesized from C2 protein by alternative splicing and have an additional13-amino-acids. It is localized in nucleus and has leucine zipper-like RNA-binding motif. The hnRNP-C proteins have a single ribonucleoprotein (RNP) motif RNA-binding domain (RBD) of 80 to 100 amino acid long.
免疫原
RNPs eluted from oligo (dT) cellulose column.
應用
Monoclonal Anti-hnRNP-C1/C2 antibody produced in mouse has been used in:
- antibody microarray
- western blotting
- enzyme linked immunosorbent assay (ELISA)`
- immunoprecipitation
- immunocytochemistry
生化／生理作用
Heterogeneous nuclear ribonucleoproteins C1/C2(HnRNP C1/C2) is involved in protein translation, mRNA biogenesis and transport. The hnRNP-C proteins preferentially bind to uridine-rich RNA sequences. Oligomerization of the protein through leucine rich regions in its C-terminal end is important for RNA binding. Mutation of the hnRNPC gene is implicated in embryonic lethal phenotype.
外觀
Solution in phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Nathalie Meyer-Schaller et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(30), 12365-12370 (2009-07-21)
Cullin (Cul)-based E3 ubiquitin ligases are activated through the attachment of Nedd8 to the Cul protein. In yeast, Dcn1 (defective in Cul neddylation 1 protein) functions as a scaffold-like Nedd8 E3-ligase by interacting with its Cul substrates and the Nedd8
A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells
Cantu C, et al.
Nucleic Acids Research, 39(2), 486-501 (2010)
Nuclear efflux of heterogeneous nuclear ribonucleoprotein C1/C2 in apoptotic cells: a novel nuclear export dependent on Rho-associated kinase activation
Lee HH, et al.
Journal of Cell Science, 117(23), 5579-5589 (2004)
Role of human heterogeneous nuclear ribonucleoprotein C1/C2 in dengue virus replication
Dechtawewat T, et al.
Virology Journal, 12(1), 14-14 (2015)
The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function
Yamaguchi T, et al.
Science Signaling, 11(516), eaan3638-eaan3638 (2018)
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