推荐产品
生物源
rabbit
品質等級
抗體表格
affinity purified immunoglobulin
抗體產品種類
primary antibodies
等級
Powered by Bethyl Laboratories, Inc.
物種活性
human
技術
immunoprecipitation (IP): 2-4 μg/mg
western blot: 1:2000-1:10,000
登錄號
NP_001370.1
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
rabbit ... DNMT1(1786)
免疫原
The epitope recognized by PLA0011 maps to a region between residue 700 and 750 of human DNA-Methyltranserase 1 using the numbering given in entry NP_001370.1 (GeneID 1786).
外觀
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide
其他說明
DNA methyltransferase 1 (DNMT1) catalyzes the methylation of the 5′-cytosine in the dinucleotide sequence, CpG. DNMT1 is thought to be responsible for the regulation of methylation patterns that are important in development and influence gene expression in a time- and tissue-specific manner.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Clara Dees et al.
The Journal of clinical investigation, 130(5), 2347-2363 (2020-01-29)
Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an "autonomous," self-maintaining profibrotic phenotype
Carlos Alberto Valencia Antúnez et al.
Oncology reports, 32(5), 2093-2103 (2014-09-06)
Carcinogenesis is driven by the accumulation of mutations and abnormal DNA methylation patterns, particularly the hypermethylation of tumor‑suppressor genes. Changes in genomic DNA methylation patterns are established by the DNA methyltransferases (DNMTs) family: DNMT1, DNMT3a and DNMT3b. The DNMTs are
Mina Sasaki et al.
Biochemical and biophysical research communications, 452(3), 622-628 (2014-09-03)
Reactive oxygen species (ROS) can cause severe damage to DNA, proteins and lipids in normal cells, contributing to carcinogenesis and various pathological conditions. While cellular senescence arrests the early phase of cell cycle without any detectable telomere loss or dysfunction.
Ming Li et al.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 26(4), 371-381 (2014-09-19)
To better understand the contribution of dysregulated DNA methyltransferase 1 (DNMT1) expression to the progression and biology of clear cell renal cell carcinoma (ccRCC). We examined the differences in the expression of DNMT1 in 89 ccRCC and 22 normal tissue
Haiyan Huang et al.
Biochemical and biophysical research communications, 452(3), 708-714 (2014-09-10)
Benzo(a)pyrene (BaP) is a known carcinogen cytotoxic which can trigger extensive cellular responses. Many evidences suggest that inhibitors of poly(ADP-ribose) glycohydrolase (PARG) are potent anticancer drug candidates. However, the role of PARG in BaP carcinogenesis is less understood. Here we
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