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product name
帕罗西汀 盐酸盐 半水合物, ≥98% (HPLC), powder
品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white
起源
GlaxoSmithKline
SMILES 字串
O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3
InChI
1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1
InChI 密鑰
QRQSGFFISBKLMZ-YHOFXEKLSA-N
基因資訊
human ... SLC6A4(6532)
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應用
盐酸帕罗西汀半水合物已被用于：作为抗抑郁药，在体外用于研究其对胚胎大鼠海马神经干细胞（NSC）的影响 ；作为一种CYP 2D6抑制剂，研究其对人重组CYP 2D6体外生产酚类代谢物的影响；作为抗抑郁药，研究其对大鼠原代海马神经元垂体腺苷酸环化酶激活多肽（PACAP）、其受体和脑源性神经营养因子（BDNF）表达的影响
生化／生理作用
帕罗西汀是一种苯基哌啶衍生物。它具有穿过胎盘的能力。研究已发现帕罗西汀会增加先天性心脏畸形的风险。它可能在激素替代疗法中用于治疗更年期期间的血管舒缩症状。它已被发现可改善恐慌症、强迫症和社交恐惧症。
盐酸帕罗西汀半水化合物是选择性 5-羟色胺再摄取抑制剂 (SSRI) 中作用最强、选择性最强的一种；抗抑郁药
特點和優勢
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
法律資訊
经GlaxoSmithKline许可销售
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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